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Caffeine is an integral part of beverages, food, and medications. Severe intoxication of caffeine is rare, and reports are even scarcer. However, over-the-counter, unregulated sale of performance-enhancing compounds, such as caffeine, turns high-dose consumption into a real concern. Severe intoxication may be fatal, usually by malignant cardiac arrhythmia. We report a case of a 23-year-old university student who accidentally consumed about 100 times the amount present in an expresso of anhydrous caffeine.
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http://dx.doi.org/10.7759/cureus.21045 | DOI Listing |
Toxicon
September 2025
Department of Pathology, College of Medicine, King Khalid University, P.O. 641, Abha, 61421, Saudi Arabia; Department of Forensic Medicine and Clinical Toxicology, Mansoura University, Egypt.
Titanium dioxide nanoparticles (TiO-NPs) are used in the production of various industrial and commercial products and reported to cause neurotoxicity in Sprague Dawley rats. Fortunellin (FRN) is a potent flavonoid with diverse biological properties. This research experiment was performed to explore the protective role FRN against TiO-NPs induced brain damage.
View Article and Find Full Text PDFDrug Chem Toxicol
September 2025
Immunoregulation Research Center, Shahed University, Tehran, Iran.
Sulfur mustard (SM), a chemical warfare agent, inflicts severe acute and chronic health effects. This study investigates the impact of SM-induced oxidative stress on telomere length (TL) and shelterin gene expression, which are crucial for telomere maintenance in exposed veterans. This study involved SM-exposed veterans and non-exposed controls.
View Article and Find Full Text PDFJ Vet Emerg Crit Care (San Antonio)
August 2025
Department of Veterinary Emergency and Critical Care, Veterinary Specialty Center, Bannockburn, Illinois, USA.
Objective: To describe hypoglycemia secondary to zinc toxicosis in a dog.
Case Summary: A 3-year-old spayed female Pug weighing 9.0 kg presented with lethargy and labored breathing.
Biomedicines
August 2025
Cognitive and Clinical Neuroimaging Core (CCNC), McLean Hospital, Belmont, MA 02478, USA.
: Cannabidiol (CBD) is a non-intoxicating cannabinoid touted for a variety of medical benefits, including alleviation of anxiety. While legalization of hemp-derived products in the United States (containing ≤0.3% delta-9-tetrahydrocannabinol [d9-THC] by weight) has led to a rapid increase in the commercialization of hemp-derived CBD products, most therapeutic claims have not been substantiated using clinical trials.
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