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Article Abstract

The vaccine candidate CVnCoV (CUREVAC) showed surprisingly low efficacy in a recent phase 3 trial compared with other messenger RNA (mRNA) vaccines. Here we show that the low efficacy follows from the dose used and the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants and is predicted by the neutralizing antibody response induced by the vaccine.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9383389PMC
http://dx.doi.org/10.1093/cid/ciac075DOI Listing

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