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http://dx.doi.org/10.1016/j.bulcan.2021.12.010 | DOI Listing |
Chem Biodivers
September 2025
Department of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk, Republic of Korea.
One of the most significant problems facing the scientific community in the 21st century is diabetes mellitus. There is an urgent need to create new powerful compounds that can fight this terrible disease because the number of instances of diabetes and drug-resistant diabetes is rising. We have synthesized a novel series of thiazole-derived thiadiazole-based Schiff base derivatives (1-10) in an effort to identify potential antidiabetic agents.
View Article and Find Full Text PDFPlant J
September 2025
Plant Physiology, Matthias Schleiden Institute for Genetics, Bioinformatics and Molecular Botany, Friedrich Schiller University Jena, 07743, Jena, Germany.
Progestogens and androgens are steroids found in a wide range of plants, but little is known about their physiological functions. In this study, we sowed seeds of angiosperms on progestogen- and androgen-containing medium and analysed their morphological effects. We further investigated the effects of progesterone and testosterone on brassinosteroid profiles and gene expression in A.
View Article and Find Full Text PDFJ Am Chem Soc
September 2025
Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.
Among the different types of HIV-1 maturation inhibitors, those that stabilize the junction between the capsid protein C-terminal domain (CA) and the spacer peptide 1 (SP1) within the immature Gag lattice are promising candidates for antiretroviral therapies. Here, we report the atomic-resolution structure of CA-SP1 assemblies with the small-molecule maturation inhibitor PF-46396 and the assembly cofactor inositol hexakisphosphate (IP6), determined by magic angle spinning (MAS) NMR spectroscopy. Our results reveal that although the two PF-46396 enantiomers exhibit distinct binding modes, they both possess similar anti-HIV potency.
View Article and Find Full Text PDFPLoS One
September 2025
Departamento de Biología, Escuela de Ciencias e Ingeniería, Universidad del Rosario, Bogotá, Colombia.
Honey bees (Apis mellifera) are essential pollinators threatened by sublethal effects of pesticides such as imidacloprid, a widely used neonicotinoid that disrupts the central nervous system. However, many of the systemic effects are poorly understood, especially on the physiological homeostasis of the honey bee. We evaluated the effects of oral administration of imidacloprid and the flavonol rutin on the properties of extracellular fluid (ECF) in Apis mellifera.
View Article and Find Full Text PDFAnesth Analg
September 2025
From the Department of Anesthesiology.
Background: Total knee arthroplasty (TKA) is a surgical procedure that induces intense acute postoperative pain, but the mechanisms that amplify post-TKA pain remain incompletely understood. Endocannabinoids, such as 2-arachidonoylglycerol (2-AG), are endogenous lipids that can produce antinociceptive effects. However, hydrolysis of 2-AG by monoacylglycerol lipase (MAGL) generates arachidonic acid, the precursor to a host of eicosanoids that enhance pain.
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