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The protozoan is one of the major causative pathogens of diarrhoea in young ruminants; therefore, it causes economic losses and impairs animal welfare. Besides , there are many other non-infectious and infectious factors, such as rotavirus, , and , which may lead to diarrhoeic disease in young livestock. Often, more than one infectious agent is detected in affected animals. Little is known about the interactions bet-ween simultaneously occurring pathogens and their potential effects on the course of disease. In this review, a brief overview about pathogens associated with diarrhoea in young ruminants is presented. Furthermore, information about coinfections involving is provided.
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http://dx.doi.org/10.3390/pathogens11010103 | DOI Listing |
Proc Natl Acad Sci U S A
September 2025
Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.
Despite the clinical significance of many nonenveloped viruses, the molecular mechanisms of their internalization and membrane penetration are not well understood. Rotaviruses (RVs) are nonenveloped double-stranded RNA viruses and the leading cause of severe dehydrating diarrhea in infants and young children. We identified fatty acid 2-hydroxylase (encoded by ) in the fatty acid 2-hydroxylation pathway as a proviral gene that supports RV infection.
View Article and Find Full Text PDFMedicine (Baltimore)
August 2025
Department of Breast and Thyroid Surgery, Shaoxing People's Hospital, The First Hospital of Shaoxing University, Shaoxing, Zhejiang Province, China.
Rationale: Esophageal fistula is a rare and serious complication after endoscopic thyroidectomy. Current research focuses more on surgical treatment, while there are few treatment plans for esophageal fistula after endoscopic thyroidectomy. There is currently no standardized intervention for esophageal fistula after thyroid surgery.
View Article and Find Full Text PDFBMC Public Health
September 2025
Uganda Public Health Fellowship Program, Uganda National Institute of Public Health, Kampala, Uganda.
Background: Cholera is endemic in Uganda with periodic outbreaks occurring annually. On July 24, 2023, Uganda's Ministry of Health confirmed a cholera outbreak in Sigulu Island, Namayingo District. We investigated to determine its magnitude, identify possible exposures, and recommend evidence-based control interventions.
View Article and Find Full Text PDFBMC Med
September 2025
Department of Microbiota Medicine & Medical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210011, Jiangsu, China.
Background: Bile acid malabsorption (BAM) or bile acid diarrhea (BAD) complicates more than 30% of Crohn's disease (CD), yet no non-invasive biomarker reliably identifies patients who will benefit from fecal microbiota transplantation (FMT). We investigated whether serum 7α-hydroxy-4-cholesten-3-one (C4), a hepatic bile-acid synthesis precursor, can predict BAM and FMT response in inflammatory bowel disease (IBD).
Methods: We included 106 pairs of IBD patients treated with FMT from two longitudinal cohorts of prospective trials and 24 matched healthy individuals to identify a multi-omics analysis of microbiota-metabolism and evaluate real-world effectiveness of FMT.
BMC Infect Dis
September 2025
Infectious Diseases Research Center (IDRC), Arak University of Medical Sciences, Arak, Iran.
Background: Giardiasis is recognized as the most prevalent enteric protozoal infection worldwide. Although gastrointestinal symptoms are the most common manifestations of giardiasis, several studies have reported cases of urticaria associated with this infection. Urticaria is a common mast cell-dependent disorder characterized by wheals, angioedema, or both.
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