Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9125400 | PMC |
| http://dx.doi.org/10.1161/CIRCRESAHA.121.320599 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Metabolic interplay of SCFA's in the gut and oral microbiome: a link to health and disease.
Front Oral Health
August 2025
Conservative Dentistry and Endodontics, AB Shetty Memorial Institute of Dental Sciences, Nitte (deemed to be) University, Mangalore, India.
Short-chain fatty acids (SCFAs), primarily acetate (C2), propionate (C3), and butyrate (C4), are crucial microbial metabolites formed by the fermentation of dietary fibers by gut microbiota in the colon. These SCFAs, characterized by fewer than six carbon atoms, serve as an essential energy source for colonic epithelial cells and contribute approximately 10% of the body's total energy requirement. They are central to maintaining gut health through multiple mechanisms, including reinforcing intestinal barrier function, exerting anti-inflammatory effects, regulating glucose and lipid metabolism, and influencing host immune responses.
View Article and Find Full Text PDFUmbelliferone Alleviates Sleep Deprivation Induced Cognitive Impairment through the Modulation of Gut Microbiota.
J Agric Food Chem
September 2025
Department of Food Science and Engineering, Ningbo University, Ningbo 315211, P.R. China.
Sleep deprivation (SD) is a major contributor to cognitive impairment, often accompanied by central neuroinflammation and gut microbiota dysbiosis. The tryptophan (TRP) pathway, activated via indoleamine 2,3-dioxygenase (IDO), serves as a critical link between immune activation and neuronal damage. Umbelliferone (UMB), a naturally occurring coumarin compound, possesses anti-inflammatory, antioxidant, and microbiota-modulating properties.
View Article and Find Full Text PDFHypoxia Aggravates Myocardial Ischemia/Reperfusion Injury Through the Promotion of Ferroptosis via ACSL4 Lactylation.
J Cardiovasc Transl Res
September 2025
Department of Cardiology, Bei'an Hospital, Beidahuang Group, Heihe, 164000, Heilongjiang Province, China.
Myocardial ischemia/reperfusion injury (MIRI) worsens ischemic damage, with ferroptosis as a key mediator of this iron-dependent cell death. Lactylation, a novel epigenetic modification, remains poorly understood in MIRI-associated ferroptosis. This study aimed to elucidate the mechanistic link between lactylation and ferroptosis in MIRI.
View Article and Find Full Text PDFStructure of entinostat Form B, CHNO, derived using laboratory powder diffraction data and density functional techniques.
Acta Crystallogr E Crystallogr Commun
September 2025
Department of Chemistry Faculty of Science University of Lucknow,Lucknow 226007 Uttar Pradesh India.
The crystal structure of entinostat Form B, CHNO, has been solved and refined using laboratory X-ray powder diffraction data, and optimized using density functional techniques. Entinostat crystallizes in space group 2 and the crystal structure consists of inter-locking layers of entinostat mol-ecules parallel to the plane. A strong N-H⋯N hydrogen bond links the mol-ecules into zigzag chains propagating along the -axis direction.
View Article and Find Full Text PDFThe crystal structures and Hirshfeld surface analysis of the 2-iodophenyl- and 4,5-difluoro-2-iodophenyl derivatives of benzenesulfonamide.
Acta Crystallogr E Crystallogr Commun
September 2025
Department of Organic Chemistry University of Madras, Guindy Campus Chennai-600 025 Tamilnadu India.
Two new benzene-sulfonyl derivatives, -(2-iodo-phen-yl)benzene-sulfonamide, CHINO, (), and -(4,5-di-fluoro-2-iodo-phen-yl)benzene-sulfonamide, CHFINOS, () were synthesized and structurally characterized. In both mol-ecular structures, the conformation of the N-C bond in the -SO-NH-C segment is relative to the S=O bond. For (), the crystal packing is dominated by N-H⋯O hydrogen-bonding inter-actions that link the mol-ecules into chains extending parallel to [010].
View Article and Find Full Text PDF