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http://dx.doi.org/10.1113/JP282389 | DOI Listing |
Neurobiol Aging
September 2025
Departamento de Farmacobiología. Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México 14330, Mexico. Electronic address:
The physiological decline associated with aging is often accompanied by a progressive deterioration in cognitive processing abilities driven by a series of cellular dysfunctions that remain poorly understood. In the hippocampus, a critical area for learning and memory, aging affects the functional expression of ionotropic and metabotropic receptors, including the metabotropic glutamate receptors (mGluRs). mGluRs play a critical role in multiple cellular functions, including modulation of ion channels and intrinsic excitability, synaptic transmission, and induction of synaptic plasticity, processes considered part of the cellular substrates for learning and memory.
View Article and Find Full Text PDFCell Calcium
August 2025
Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, 100081, China. Electronic address:
DREADD (design receptors exclusively activated by designer drugs) is a widely used powerful tool designed to study specific cellular functions. However, off-target effects of chemogenetic activators, including clozapine N-oxide (CNO) and deschloroclozapine (DCZ), have been reported. In our study, we demonstrated the direct off-target effects of CNO and DCZ on basal Ca levels in the locus coeruleus nucleus in both neurons and astrocytes by combining viral microinjection, Ca imaging and electrophysiology.
View Article and Find Full Text PDFActa Pharmacol Sin
August 2025
Lepu Medical Technology (Beijing) Co., Ltd, Beijing, 102200, China.
N-methyl-D-aspartate receptors (NMDARs) are calcium-permeable ionotropic glutamate receptors broadly expressed throughout the central nervous system, where they play crucial roles in neuronal development and synaptic plasticity. Among the various subtypes, the GluN1/GluN3A receptor represents a unique glycine-gated NMDAR with notably low calcium permeability. Despite its distinctive properties, GluN1/GluN3A remains understudied, particularly with respect to pharmacological tools development.
View Article and Find Full Text PDFExp Eye Res
August 2025
Departmento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politecnico Nacional, Av. IPN 2508, San Pedro Zacatenco, CDMX, 07360, Mexico. Electronic address:
Signal transmission in the visual pathway is carried by glutamate, the major excitatory neurotransmitter in the vertebrate brain. Ionotropic and metabotropic receptors mediate the actions of this amino acid. A tight regulation of extra-synaptic glutamate concentrations is needed for the selective activation of its receptors as a function of the day/night cycle.
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