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Purulia is a malaria-prone district in West Bengal, India, with approximately half of the blocks defined as malaria endemic. We analyzed the malaria case in each block of the Purulia district from January 1, 2016, to December 31, 2020. As per the API, 20 blocks of Purulia were assigned to four different categories (0-3) and mapped using ArcGIS software. An exponential decay model was fitted to forecast the trend of malaria cases for each block of Purulia (2021-2025). There was a sharp decrease in total malaria cases and API from 2016 to 2020 due to the mass distribution of LLINs. The majority of cases (72.63%) were found in ≥ 15-year age group. Males were more prone to malaria (60.09%). Malaria was highly prevalent among Scheduled Tribes (48.44%). Six blocks were reported in Category 3 (high risk) and none in Category 0 (no risk) in 2016, while no blocks were determined to be in Category 3, and three blocks were in Category 0 in 2020. The exponential decay model prediction is oriented towards gaining malaria-free status in thirteen blocks of Purulia by 2025. This study will incite the government to uphold and strengthen the current efforts to meet the malaria elimination goals.
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http://dx.doi.org/10.1038/s41598-021-04399-x | DOI Listing |
Recent Pat Anticancer Drug Discov
September 2025
School of Pharmacy, Devi Ahilya Vishwavidalaya, Indore, M.P., India.
Artemisinin, a natural compound derived from Artemisia annua, has significantly impacted the treatment of malaria and has shown promise in various other therapeutic applications. This review explores the molecular structure of artemisinin and its derivatives, as well as advancements in synthetic and semi-synthetic production methods, and their broader therapeutic effects beyond malaria, including potential uses in cancer, neurological disorders, and viral infections. It also discusses contemporary drug delivery innovations, such as nanoparticles and liposomal systems, which aim to enhance the bioavailability and targeted action of artemisinin, while addressing issues of drug resistance, particularly in parasitic diseases like malaria.
View Article and Find Full Text PDFActa Trop
September 2025
Guangdong Provincial Key Laboratory of Aquatic Economic Animals, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China;. Electronic address:
Malaria is still one of the most important parasitic diseases with millions of cases reported globally every year. Combination therapies of artemisinin or its derivatives, with a partner drug, are the first-and second-line treatments for malaria. However, recently, artemisinin partial resistance or tolerance has emerged and emphasizes the need for new therapeutic approaches to malaria.
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September 2025
Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand; Centre for Tropical Medicine and Global Health
Background: The increasing recognition of zoonotic malaria, particularly from Plasmodium species infecting non-human primates (NHP), poses significant diagnostic challenges. Performance of human malaria Rapid Diagnostic Tests (RDTs) has not been evaluated in simian malaria.
Methods: A total of 131 blood samples from NHP hosts with confirmed malaria were analyzed using 14 different commercially available RDTs, detecting the antigens P.
Acta Trop
September 2025
Université Nazi BONI (UNB), Unité de Formation et de Recherche en Sciences de la Vie et de la Terre, Bobo-Dioulasso, Burkina Faso; Institut de Recherche en Sciences de la Santé, Direction Régionale de l'Ouest, Bobo-Dioulasso, Burkina Faso; Institut National Santé Publique, Centre MURAZ, Bobo-Di
An entomological surveillance was carried out in two districts of western Burkina Faso to assess the impact of mass-distributed next-generation long-lasting insecticidal nets (LLINs) (Piperonyl Butoxide (PBO) LLINs and Interceptor® G2) on Anopheles gambiae s.l. populations, focusing on insecticide resistance trends and residual malaria transmission patterns, along with their environmental and operational determinants.
View Article and Find Full Text PDFMicron
September 2025
Laboratório de Desenvolvimento e Aplicações de Nanomateriais da Amazônia (LADENA), Departamento de Física de Materiais, Universidade Federal do Amazonas, Manaus, AM 69067-005, Brazil. Electronic address:
This study investigates the nanoscale surface morphology of Anopheles darlingi and Anopheles aquasalis mosquito wings using Atomic Force Microscopy (AFM) and fractal analysis. High-resolution 3D AFM imaging revealed pronounced inter- and intra-species differences, with the ventral surface of An. darlingi (V-Ad) exhibiting the greatest roughness (Sq = 45.
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