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Mazes are broadly used to investigate animal decision-making and spatial learning. However, they have been sparsely employed to explore behavior and training-improved performance. This protocol describes a highly reproducible, low-cost maze platform, made of the standard, agar-based, nematode culturing material. It can be used to reliably assess ' maze behavior, and we have recently applied this protocol to establish multisensory learning. Limitations include challenges in locomotion tracking and in distinguishing learning formation versus retrieval. For complete details on the use and execution of this protocol, please refer to Gourgou et al. (2021).
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http://dx.doi.org/10.1016/j.xpro.2021.100829 | DOI Listing |
Exp Neurobiol
August 2025
Department of Biological Sciences, Konkuk University, Seoul 05029, Korea.
This study investigated the learning strategy preferences of 11-month-old APP/PS1 double transgenic (Tg) mice, a well-established murine model of Alzheimer's disease (AD). APP/PS1 Tg and non-Tg control mice were serially trained in visual and hidden platform tasks in the Morris water maze. APP/PS1 Tg mice performed poorly in visual platform training compared with non-Tg mice but performed as well as non-Tg mice in hidden platform training.
View Article and Find Full Text PDFBrain Behav
September 2025
Department of Traditional Chinese Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Background: Cognitive impairment is a frequent complication of diabetes, yet effective treatments remain elusive. In animal models, acupuncture has shown potential in improving cognitive deficits related to diabetes, but a comprehensive evaluation of its efficacy is lacking.
Materials And Methods: We systematically searched seven databases (PubMed, Web of Science, Embase, OVID, SinoMed, CNKI, and Wanfang) from their inception through January 1, 2025.
Gels
August 2025
Drug Design, Development and Delivery Laboratory, Department of Bioengineering, Clemson University, Clemson, SC 29634, USA.
Functional recovery after traumatic brain injury (TBI) is hindered by progressive neurodegeneration resulting from neuroinflammation and other secondary injury processes. Dexamethasone (DX), a synthetic glucocorticoid, has been shown to reduce inflammation, but its systemic administration can cause a myriad of other medical issues. We aim to provide a local, sustained treatment of DX for TBI.
View Article and Find Full Text PDFFront Aging Neurosci
August 2025
Institute of Gerontology, Wayne State University, Detroit, MI, United States.
Introduction: Wayfinding is a cognitive ability that supports accurate spatial navigation and declines in this ability adversely affect independent living in older age. The cognitive map represents environmental details, such as landmark cues, relative to the goal location. Distal cues appear to be less effective than proximal ones in precisely locating the goal.
View Article and Find Full Text PDFChanges in behavioral parameters in the open field and elevated plus maze tests were studied in female rats with experimental osteoarthritis of the temporomandibular joint (TMJ) caused by intra-articular injection of sodium monoiodoacetate (16 mg/kg). In the elevated plus maze, the animals with experimental pain syndrome demonstrated the following dynamics of behavioral parameters: the latency of leaving the central platform and the time spent in closed arms increased, while the number of visits to closed arms and numbers of head dips and rearings decreased on day 25 of the experiment in comparison with the baseline levels. In the open-field, the latency of the first movement and grooming time increased and the number of objects explored decreased by day 26.
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