98%
921
2 minutes
20
Peptide-based materials that have diverse structures and functionalities are an important type of biomaterials. In former times, peptide-based nanomaterials with excellent stability were constructed through self-assembly. Compared with individual peptides, peptide-based self-assembly nanomaterials that form well-ordered superstructures possess many advantages such as good thermo- and mechanical stability, semiconductivity, piezoelectricity and optical properties. Moreover, due to their excellent biocompatibility and biological activity, peptide-based self-assembly nanomaterials have been vastly used in different fields. In this review, we provide the advances of peptide-based self-assembly nanostructures, focusing on the driving forces that dominate peptide self-assembly and assembly mechanisms of peptides. After that, we outline the synthesis and properties of peptide-based nanomaterials, followed by the applications of functional peptide nanomaterials. Finally, we provide perspectives on the challenges and future of peptide-based nanomaterials.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8668426 | PMC |
http://dx.doi.org/10.1016/j.bioactmat.2021.09.029 | DOI Listing |
Trends Biochem Sci
August 2025
Centro de Análises Proteômicas e Bioquímicas, Programa de Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, Brasília, Distrito Federal, Brazil; S-Inova Biotech, Pós-Graduação em Biotecnologia, Universidade Católica Dom Bosco, Campo Grande, Mato Gr
Antimicrobial peptides (AMPs) have emerged as promising alternatives owing to their broad-spectrum activity and reduced potential for resistance. Recent advances have highlighted the role of peptide self-assembly in enhancing the stability, bioavailability, and efficacy of AMPs. Through non-covalent interactions, self-assembly enables the formation of nanostructures, including nanofibers, nanotubes, and micelles.
View Article and Find Full Text PDFACS Appl Mater Interfaces
September 2025
Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, Tennessee 37235, United States.
Vaccine adjuvants stimulate innate immunity to enhance and shape adaptive immune responses. However, approved adjuvants typically elicit weak CD8 T cell responses to protein- and peptide-based vaccines, motivating an investigation into the discovery and testing of new adjuvants. Unedited forms of endogenous Alu RNAs are sensed by pattern recognition receptors (PRRs) to trigger sterile inflammation, and therefore we hypothesized that synthetic Alu RNA molecules could be harnessed as vaccine adjuvants.
View Article and Find Full Text PDFACS Appl Bio Mater
August 2025
Department of Chemistry, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward Island C1A 4P3, Canada.
Peptide-based self-assembled materials are being investigated as a biodegradable option with various biomedical applications such as drug-delivery carriers and as biosensors. In this study, we report the mechanism of action of a synthetic β-sheet and turn rich macrocyclic host defense peptide that self-assemble in the form of nanoparticles and stimulate naïve and tumor-associated macrophages, resulting in the production of pro-inflammatory mediators in macrophage monoculture and in a macrophage/triple-negative breast cancer (TNBC) coculture model. Our results show that macrocyclic peptide-based nanomaterials termed as mCA4 engage with toll-like receptors of macrophages, activating downstream pathways in both naïve and IL-4-pretreated macrophages, and result in the production of pro-inflammatory mediators by the immune cells.
View Article and Find Full Text PDFDalton Trans
August 2025
Department of Chemistry, School of Advanced Sciences (SAS), Vellore Institute of Technology, Vellore-632014, Tamil Nadu, India.
Metallic compounds have shown great promise as anticancer treatments because of their varied mechanisms of action, decreased side effects, and ability to overcome drug resistance. The search for alternative metal-based therapies has been driven by the severe toxicity, drug resistance, and poor selectivity of platinum-based complexes like cisplatin, carboplatin, and oxaliplatin, despite their notable clinical effectiveness. Their clinical translation is made difficult by issues such as off-target toxicity, low absorption, and poor solubility.
View Article and Find Full Text PDFWiley Interdiscip Rev Nanomed Nanobiotechnol
August 2025
Stem Cell and Regenerative Biotechnology Major, School of Advanced Biotechnology, College of Institute of Science and Technology, Molecular & Cellular Reprogramming Center, Institute of Advanced Regenerative Science, Institute of Health, Aging & Society, Konkuk University, Seoul, Republic of Korea.
Arthritic diseases are a significant global health challenge, highlighting the urgent need for innovative therapeutic strategies. Extracellular vesicles (EVs) have emerged as promising candidates for treating various intractable diseases. This review explores the therapeutic potential of engineered EVs in joint diseases, particularly in comparison to their parental stem cells.
View Article and Find Full Text PDF