Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Induction of oxidative stress events has been shown to be associated with lithium (Li) hypothyroidism induction. Metformin (MET) is a commonly used antidiabetic drug with multiple properties including antiproliferative activity, antioxidant potency, and is used in polycystic ovarian syndrome treatment. Here, in this study, we aimed to investigate the effect of different doses of MET on Li-induced hypothyroidism for elucidating its mechanism of action. The obtained results demonstrated the oxidative stress reduction in thyroid tissues upon MET treatment. Besides this, the biochemical analysis revealed a significant reduction in T and TSH levels (down to 2 ng/ml and 0.05 µU/ml, respectively) in coordination with an observable reduction in T level (up to 2.1 ng/ml). Also, a significant reduction in Li-related tissue damages including changes in the morphology and the size of follicles, rate of vascularity, detachment of follicular cells, inflammatory cells infiltration, and follicular cells hypertrophy and disruption was observed. Ultimately, regarding the significant improvement in thyroid tissues and valuable antioxidant activity determined in tissues treated with MET, it is concluded that MET co-administration with Li can significantly reduce the negative effects of Li and enhance the efficacy of Li therapy.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/jbt.22977 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effects of Hypothyroidism on the Extracellular Matrix of the Vocal Folds of Adult Female Rats.
Otolaryngol Head Neck Surg
September 2025
Department of Otorhinolaryngology, Head and Neck Surgery, Universidade Federal de São Paulo/Escola Paulista de Medicina (UNIFESP/EPM), Sao Paulo, Sao Paulo, Brazil.
Objective: The aim of the present study was to investigate the changes in the extracellular matrix of the vocal folds of female rats after induction of hypothyroidism.
Study Design: Prospective and experimental study.
Setting: Single tertiary center.
Perinatal methimazole exposure impairs the distribution and function of layer 5 neurons in the mouse auditory cortex.
Sci Rep
August 2025
Department of Biosciences, Graduate School of Science and Engineering, Soka University, Hachioji, Tokyo, 192-8577, Japan.
Methimazole (MMI) is an antithyroid drug often prescribed for hyperthyroid conditions. While perinatal MMI exposure is used to model hypothyroidism in rodents, resulting in auditory cortex malformation, mice are reportedly less effective in lowering serum thyroxine levels. This raises the question on MMI-induced hypothyroidism being the underlying cause of cortical malformation.
View Article and Find Full Text PDFLong-term outcomes of pituitary radiotherapy and their predictive factors in childhood and adolescent-onset Cushing disease.
Eur J Endocrinol
July 2025
Department of Endocrinology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra 400012, India.
Objective: Radiotherapy (RT) is an established second-line treatment in adult Cushing disease (CD). Data on pituitary RT in childhood and adolescent-onset CD is scarce. This study aims to demonstrate the effectiveness and long-term safety of fractionated conformal-RT (CRT) in childhood and adolescent-onset CD patients.
View Article and Find Full Text PDFGeneral anesthesia in patients with undiagnosed hypothyroidism can lead to neurological, pulmonary, and cardiovascular complications. We report a case of hypothyroidism in a patient with treatment-resistant depression detected intraoperatively based on multiple clinical findings. A 49-year-old woman was scheduled for orthognathic surgery for mandibular prognathism.
View Article and Find Full Text PDFAdult-onset hypothyroidism induces granulosa cell apoptosis and affects ovarian follicle development in rats.
Front Cell Dev Biol
May 2025
Reproductive Medical Center, Department of Obstetrics and Gynecology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.
Introduction: Hypothyroidism is a common endocrine disorder in women, which could lead to ovulation disorders and infertility, however, the effects of adult-onset hypothyroidism on ovarian development and gene expression characteristics need further study.
Methods: Here we conducted an adult-onset hypothyroidism rat model by using the methimazole (MMI) induction, then the hormone level changes and ovarian development were evaluated, furthermore, the effects of gene expression of granulosa cells and oocytes were detected by using single-cell RNA sequencing.
Results: Our results showed that, in addition to a decrease in thyroid hormones, the body weight was significantly reduced, while the estrus cycle was prolonged in the hypothyroidism group.