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Trichilemmal cysts (TCs) are the most common cystic lesions arising on the scalp and up to 2% give rise to a proliferating trichilemmal tumor (PTT). A rare subset of PTTs are termed malignant due to their histologic characteristics, aggressive behavior and potential for metastasis. The histological hallmark of TCs and PTTs is the absence of a granular layer resulting in abrupt trichilemmal keritanization.
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http://dx.doi.org/10.36849/jdd.5978 | DOI Listing |
Biosens Bioelectron
December 2025
Integrative Biomedical Materials and Nanomedicine Laboratory, Medicine and Life Sciences Department, Universitat Pompeu Fabra, Carrer Del Doctor Aiguader 88, 08003, Barcelona, Spain. Electronic address:
Labile Zn is emerging as a quantitative driver, not just a biomarker, of metastasis, yet rapid, second-resolved intracellular measurement remains elusive. Here we engineer terpyridine-functionalised, hollow Au@SiO nanocapsules (NCs@TPY) and couple their SERS signal to cell-specific partial-least-squares (PLS) chemometrics, yielding an 8-log dynamic range (10 - 10 M), a low-nanomolar detection limit and ≤4.5 % cross-validated error while rejecting Ca/Mg interference.
View Article and Find Full Text PDFAm J Case Rep
July 2025
Department of Oral and Maxillofacial Surgery, Azerbaijan Medical University, Baku, Azerbaijan.
BACKGROUND Proliferating trichilemmal cysts, also referred to as pilar cysts, are benign adnexal tumors in the scalp diagnosed most commonly in middle-aged women. The cysts can be large and require careful surgical resection, as malignant variants can exist. Although uncommon, it is rare for these tumors to reach large sizes.
View Article and Find Full Text PDFTheriogenology
October 2025
Department of Animal Reproduction, National Institute for Agriculture and Food Research and Technology (INIA-CSIC), Cta de La Coruña Km 5.9, 28040, Madrid, Spain; Programa de Medicina Veterinaria y Zootecnia, Grupo Kyron, Corporación Universitaria del Huila (CORHUILA), Huila, Colombia. Electronic
The oviduct and uterus provide a supportive environment for early embryonic development, where effective embryo-maternal communication is essential for pregnancy success. Extracellular vesicles (EVs) from oviductal (OF) and uterine fluids (UF) are key mediators of this communication, transporting bioactive molecules such as proteins, lipids, DNA, and regulatory RNAs. Among these, microRNAs (miRNAs) are particularly interesting due to their role in modulating reproductive processes.
View Article and Find Full Text PDFMol Med
March 2025
INCLIVA Biomedical Research Institute, Valencia, 46010, Spain.
The anti-HER2 monoclonal antibody trastuzumab and new derivative formulations are the standard treatment for HER2-positive breast cancer. However, after 1 to 5 years of treatment, some patients acquire resistance to therapy, leading to relapse. The microRNA-449 family members were downregulated in HER2-positive breast cancer cell lines and low levels were associated with patients' worse prognosis.
View Article and Find Full Text PDFProliferating trichilemmal tumor (PTT) is a rare, benign adnexal tumor of hair follicles that commonly mimics malignancy. Excellent outcomes can be achieved with early surgical excision. Delayed presentations-as in this giant shoulder PTT-are made possible, in part, by patient education and healthcare accessibility in low-resource settings.
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