Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Marine microalgae can be used as sustainable protein sources in many fields with positive effects on human and animal health. DAPTMGY is a heptapeptide isolated from which is a microalga. In this study, we evaluated its anti-photoaging properties and mechanism of action in human immortalized keratinocytes cells (HaCaT). The results showed that DAPTMGY scavenged reactive oxygen species (ROS) and increase the level of endogenous antioxidants. In addition, through the exploration of its mechanism, it was determined that DAPIMGY exerted anti-photoaging effects. Specifically, the heptapeptide inhibits UVB-induced apoptosis through down-regulation of p53, caspase-8, caspase-3 and Bax and up-regulation of Bcl-2. Thus, DAPTMGY, isolated from , exhibits protective effects against UVB-induced damage.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8625372 | PMC |
| http://dx.doi.org/10.3390/md19110626 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[An electrostatically coupled polypeptide affinity multimodal chromatography medium for the purification of antibodies and their separation efficiency].
Sheng Wu Gong Cheng Xue Bao
August 2025
State Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.
As the need for antibody production rises, there is an urgent need to lower the costs and enhance the efficiency of the separation process. Currently, the chromatographic media used for antibody separation and purification often focus on individual properties of antibodies, such as affinity, hydrophobicity, and charge, leading to issues like low purification efficiency or inadequate adsorption capacity. To address this, an electrostatically coupled polypeptide affinity medium (FD7-3, 5-diaminobenzoic acid n-sepharose, FD7-DA-Sepharose) was developed for rapid purification of antibodies from cell culture supernatant.
View Article and Find Full Text PDFAlternative zinc binding peptides as potential tags for recombinant protein purification.
J Inorg Biochem
October 2025
Department of Chemistry, East Texas A&M University, 2600 S Neal Street, Commerce, TX 75428, USA. Electronic address:
Efficient binding of peptides and proteins to metal-chelating resins is a cornerstone of modern biochemical purification. This study evaluates a novel heptapeptide sequence, acetyl-Aa-Aa-Gly-Pro-Aa-His-Cys, where Aa = His or Asp, Aa = Cys or Asp and Aa = Tyr or Gly for its capacity to bind zinc-chelating resin consisting of divalent zinc chelated by iminodiacetate coupled to 6 % cross-linked agarose beads. Comparisons were made against the widely utilized 7 × His tag using an internal standard method with ion mobility - mass spectrometry analyses and ultra-violet absorption analyses, which quantified the binding efficiency and selectivity of these peptides under pH 8 conditions and the elution from the zinc resin using pH 3.
View Article and Find Full Text PDFThe Isolation, Structural Characterization, and Biosynthetic Pathway of Unguisin from the Marine-Derived Fungus .
Mar Drugs
May 2025
Shandong Provincial Key Laboratory of Synthetic Biology, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China.
Unguisins, a class of structurally complex cyclic peptides featuring a -aminobutyric acid residue embedded in the skeleton, exhibit diverse biological activities. Here, a new unguisin K, along with three known congeners, was isolated from the marine-derived fungus MEFC1001. The biosynthetic pathway was elucidated through gene disruption coupled with in vitro enzymatic characterization.
View Article and Find Full Text PDFGenome mining, structural elucidation and surface-active property of a new lipopeptide from Bacillus subtilis.
Microb Cell Fact
May 2025
State Key Laboratory of Bioreactor Engineering, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, P.R. China.
Background: The Bacillus genus is well known for producing structurally diverse lipopeptides, many of which exhibit remarkable surface-active and bioactive properties, such as surfactin and daptomycin. In recent years, genome mining has emerged as an effective tool for the discovery of novel natural products by predicting biosynthetic gene clusters and linking them to secondary metabolite production. However, the full biosynthetic potential of many Bacillus subtilis strains remains unexplored.
View Article and Find Full Text PDFSynthesis of Stylissamide B, a Pro-Rich Cyclic Heptapeptide Isolated From the Marine Sponge Stylissa caribica.
J Pept Sci
June 2025
Department of Chemistry and Biological Engineering, Graduate School of Science and Engineering, Yamagata University, Yonezawa, Yamagata, Japan.
Stylissamide B was successfully synthesized for the first time using Fmoc solid-phase peptide synthesis (Fmoc-SPPS) followed by cyclization in solution phase. The Fmoc-SPPS process was monitored using the reversible detection method for amino groups (ReD-A method). The linear peptide, Pro-Pro-Ile-Tyr-Pro-Phe-Pro, was cyclized to form stylissamide B.
View Article and Find Full Text PDF