Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/s41591-021-01496-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Warm temperature-induced autophagy mediates selective degradation of TIMING OF CAB EXPRESSION 1 thus promoting plant thermomorphogenesis.
Plant Cell
September 2025
Department of Plant Sciences, College of Biological Sciences, State Key Laboratory of Plant Environmental Resilience, China Agricultural University, Beijing 100193, China.
Plant thermomorphogenesis is a critical adaptive response to elevated ambient temperatures. The transcription factor PHYTOCHROME-INTERACTING FACTOR 4 (PIF4) integrates diverse environmental and phytohormone signals to coordinate thermoresponsive growth. However, the cellular mechanisms underlying plant thermomorphogenic growth remain poorly understood.
View Article and Find Full Text PDFScenario simulation analysis of urbanization spatial pattern optimization promoting regional coordinated development: A case study of Guizhou, China.
PLoS One
September 2025
School of Statistics and Mathematics, Zhongnan University of Economics and Law, Wuhan, China.
This research delves into the optimization of urbanization spatial patterns in Guizhou Province, China. The findings reveal that with regional coordinated development as the central objective and the optimization of urbanization spatial patterns as the strategic focus, a research framework encompassing "temporal and spatial evolution of urbanization - identification and summation of pain points and difficulties - scenario simulation and optimization - strategic goal selection" is utilized to specifically tackle issues pertaining to urbanization spatial patterns. Through the construction of diverse scenarios and rigorous research analysis, an implementation pathway is derived, advocating for "strengthening the central region of Guizhou, fostering urban agglomeration development, reinforcing developmental support points, and promoting regional coordinated development.
View Article and Find Full Text PDFStatins in Acute Ischemic Stroke: Mechanisms, Resistance, and Precision Strategies for Neurovascular and Cognitive Protection.
CNS Drugs
September 2025
Global Health Neurology Lab, Sydney, NSW, 2150, Australia.
Acute ischemic stroke (AIS) remains a leading cause of mortality and long-term disability globally, with survivors at high risk of recurrent stroke, cardiovascular events, and post-stroke dementia. Statins, while widely used for their lipid-lowering effects, also possess pleiotropic properties, including anti-inflammatory, endothelial-stabilizing, and neuroprotective actions, which may offer added benefit in AIS management. This article synthesizes emerging evidence on statins' dual mechanisms of action and evaluates their role in reducing recurrence, improving survival, and mitigating cognitive decline.
View Article and Find Full Text PDFp62/SQSTM1 signaling nexus and orchestration of ERK and mTOR pathways are crucial for Bacoside A- induced autophagy-mediated apoptosis in chronic myelogenous leukemia.
Arch Pharm Res
September 2025
Department of Biosciences, JIS University, 81, Nilgunj Road, Agarpara, Kolkata, West Bengal, 700109, India.
Bacoside A (BCA), a triterpenoid saponin isolated from Bacopa monnieri, exhibits diverse pharmacological properties, including neuroprotective, hepatoprotective, anti-stress, anti-inflammatory, and anti-ulcer effects. In the present study, BCA demonstrates pronounced anticancer activity against K562 chronic myelogenous leukemia (CML) cells by modulating autophagy-apoptosis dynamics. BCA induces dose- and time-dependent cytotoxicity in K562 cells while sparing normal human peripheral blood mononuclear cells (hPBMCs) and Vero cells, indicating therapeutic selectivity.
View Article and Find Full Text PDFPatterns of Caffeine Use in Adolescents and Their Association with Sleep Quality: A Latent Class Analysis.
J Addict Nurs
September 2025
Annika Norell, PhD, School of Behavioral, Social and Legal Sciences, Örebro University, Örebro, Sweden; Faculty of Health Sciences, Kristianstad University, Kristianstad, Sweden.
Background: Although there is substantial evidence of the negative impact of caffeine use on sleep quality, few studies focus specifically on adolescents' patterns of use. This study aimed to identify patterns of caffeine use among adolescents and analyze their association with sleep quality.
Method: A cross-sectional study was conducted in southern Sweden including 1,404 adolescents aged 15-17 (56.