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http://dx.doi.org/10.1053/j.gastro.2021.10.034 | DOI Listing |
Scand J Gastroenterol
September 2025
Department of Gastrointestinal Surgery, Aalborg University Hospital, Aalborg, Denmark.
Background: Chronic pancreatitis (CP) is an inflammatory disease characterized by pain, functional deficits and increased mortality. The clinical course is unpredictable, and there are no classification systems or biomarkers to predict this. Identifying patients with high mortality risk is crucial for guiding clinical management and improving outcomes.
View Article and Find Full Text PDFGenes Genomics
August 2025
Genetic Diseases Evaluation Centre, GENTAN, İzmir, Türkiye.
Background: Early-life stress (ELS) is a significant risk factor for the development of numerous metabolic and physiological disorders later in life.
Objective: This study aims to investigate the effects of early-life stress on mitochondrial biogenesis, thermogenesis-related genes, and developmental signalling pathways in the stomach and duodenum of offspring.
Methods: This study consists of three groups: the first is the control group, and the second and third groups were randomly exposed to unpredictable maternal separation (MS) for three hours a day on postnatal days (PND) 1-14.
Int J Surg Case Rep
August 2025
Department of Surgery, Aga Khan University, Karachi 78400, Pakistan. Electronic address:
Introduction: High-voltage electrical injuries (HVI) are usually life-threatening and are commonly caused by contact with high voltage power lines. They can lead to deep burns and multi-system trauma.
Case Presentation: This report presents an atypical case of a 21-year-old male who had an accidental electrocution with high voltage power lines during a religious event, leading to a 4th-degree burn of the chest wall, right neck, pelvis, bilateral anterior thighs, perineum and both arms; the total body surface area (TBSA) was approximately 37 %.
J Ethnopharmacol
August 2025
Jiangsu Key Laboratory for High Technology Research of TCM Formulae and Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nan Jing, 210000, China. Electronic address:
Ethnopharmacological Relevance: The gut microbiome plays a crucial role in the pathology of depression. The intestinal dysbiosis associated with prolonged use of antidepressants, such as fluoxetine, can adversely affect the efficacy of these medications. Kai-Xin-San (KXS), a traditional Chinese herbal decoction, has been utilized to treat mental disorders with a long history in China.
View Article and Find Full Text PDFJ Ethnopharmacol
August 2025
Department of Colorectal Surgery, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, 215009, China. Electronic address:
Ethnopharmacological Relevance: Norisoboldine (NOR), an isoquinoline alkaloid extracted from the traditional Chinese medicinal herb Lindera aggregata (Sims) Kosterm., has been historically used for the treatment of rheumatism, abdominal pain, and gastrointestinal disorders. Its potential for modulating gut-brain axis function in the context of coexisting constipation and depression remains largely unexplored.
View Article and Find Full Text PDF