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http://dx.doi.org/10.1016/j.ijcard.2021.10.152 | DOI Listing |
Proc Natl Acad Sci U S A
September 2025
Department of Ophthalmology, Tianjin Medical University General Hospital, International Joint Laboratory of Ocular Diseases (Ministry of Education), State Key Laboratory of Experimental Hematology, Tianjin Key Laboratory of Ocular Trauma, Laboratory of Molecular Ophthalmology, Tianjin Medical Univer
Ocular fibrosis, a severe consequence of excessive retinal wound healing, can lead to vision loss following retinal injury. Proliferative vitreoretinopathy (PVR), a common form of ocular fibrosis, is a major cause of blindness, characterized by the formation of extensive fibrous proliferative membranes. Understanding the cellular origins of PVR-associated fibroblasts (PAFs) is essential to decipher the mechanisms of ocular wound healing.
View Article and Find Full Text PDFCancer Causes Control
September 2025
Orthopedics department, Guangdong Provincial Hospital of Chinese Medicine (The Second Affiliated Hospital of Guangzhou University of Chinese Medicine), Guangzhou, China.
Background: Bone metastasis (BM) in breast cancer affects patient prognosis, but its molecular mechanisms and relationship with the gut microbiome are not well understood. This study aims to explore gene expression and gut microbiome differences between BM and non-bone metastasis (BNM) patients, which could shed light on cancer progression and metastasis.
Methods: We utilized a multi-omics approach, integrating transcriptomic and microbiomic data.
BMC Neurol
September 2025
National Health Commission Key Laboratory of Molecular Probes and Targeted Diagnosis and Therapy, Harbin Medical University, Harbin, 150081, China.
Background: Hereditary ataxias (HAs) are neurodegenerative disorders characterized by progressive cerebellar degeneration, with autosomal dominant spinocerebellar ataxias (SCAs) representing the most prevalent subtype. SCA3, the most common form worldwide, is caused by CAG repeat expansions in ATXN3, resulting in pathogenic ataxin-3 aggregation. However, the underlying molecular mechanisms driving disease progression remain incompletely understood.
View Article and Find Full Text PDFSci Rep
September 2025
Department of Hematology, Heping Hospital Affiliated to Changzhi Medical College, Changzhi Medical College, Changzhi, Shanxi, PR China.
Acute myeloid leukemia (AML) exhibits significant heterogeneity in disease progression and therapeutic response, highlighting the urgent need for novel biomarkers to improve risk stratification and therapeutic targeting. In this study, we integrated multi-omics data from The Cancer Genome Atlas (TCGA, n = 151) and Genotype-Tissue Expression (GTEx, n = 337) cohorts to systematically analyze dynamic expression patterns of exosome-related genes in AML. Using univariate Cox regression and least absolute shrinkage and selection operator (LASSO) algorithms, we identified 13 exosome-associated genes (EXOSC4, TMEM109, THBS1, MYH9, HLA-DRA, CAPZB, ITGA4, MYL6, CYB5R1, PSMA2, MPO, NDST2, and CANX) and constructed a prognostic risk model.
View Article and Find Full Text PDFInt J Mol Sci
July 2025
Department of Gynecology and Obstetrics, School of Medical Sciences, State University of Campinas (UNICAMP), Campinas 13083-887, Brazil.
Obesity and metabolic dysfunction are established risk factors for luminal breast cancer, yet current preclinical models inadequately recapitulate the complex metabolic and immune interactions driving tumorigenesis. To develop and characterize an immunocompetent rat model of luminal breast cancer induced by chronic exposure to a cafeteria diet mimicking Western obesogenic nutrition, female rats were fed a cafeteria diet or standard chow from weaning. Metabolic parameters, plasma biomarkers (including leptin, insulin, IGF-1, adiponectin, and estrone), mammary gland histology, tumor incidence, and gene expression profiles were longitudinally evaluated.
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