98%
921
2 minutes
20
The sequencing of the Arabidopsis thaliana genome 21 years ago ushered in the genomics era for plant research. Since then, an incredible variety of bioinformatic tools permit easy access to large repositories of genomic, transcriptomic, proteomic, epigenomic and other '-omic' data. In this review, we cover some more recent tools (and highlight the 'classics') for exploring such data in order to help formulate quality, testable hypotheses, often without having to generate new experimental data. We cover tools for examining gene expression and co-expression patterns, undertaking promoter analyses and gene set enrichment analyses, and exploring protein-protein and protein-DNA interactions. We will touch on tools that integrate different data sets at the end of the article.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1111/tpj.15547 | DOI Listing |
Tidsskr Nor Laegeforen
September 2025
Senter for fruktbarhet og helse, Folkehelseinstituttet, og, Institutt for global helse og samfunnsmedisin, Universitetet i Bergen.
Background: The prevalence of endometriosis and adenomyosis in the Norwegian population is unknown. The aim of this study was to report on diagnoses of endometriosis, adenomyosis and related health problems among women of reproductive age.
Material And Method: We extracted specialist healthcare records of endometriosis and adenomyosis from the Norwegian Patient Registry for women aged 15 to 49 registered in Norway's National Population Register, covering the period 1 January 2008 to 31 December 2021.
Aim: This study explores the evolving landscape of gastrectomy procedures in Japan, based on nationwide surveys conducted in 2014 and 2021. It highlights changes in surgical approaches, including a growing focus on minimally invasive and function-preserving procedures, as well as the increasing consideration of postoperative quality of life (QOL).
Methods: Two nationwide questionnaire surveys were conducted in 2014 and 2021, targeting members of the Japanese Society for Gastro-surgical Pathophysiology.
Adv Pharm Bull
July 2025
Department of Telecommunications & Systems Engineering, Universitat Autònoma de Barcelona, Sabadell, 08202, Spain.
Purpose: This study explores the potential of generative AI models to aid experts in developing scripts for pharmacokinetic (PK) models, with a focus on constructing a two-compartment population PK model using data from Hosseini et al.
Methods: Generative AI tools ChatGPT v3.5, Gemini v2.
Expert Rev Gastroenterol Hepatol
September 2025
Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", Bari, Italy.
Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD) encompasses a spectrum of conditions from simple steatosis to advanced fibrosis that may represent the cradle for hepatocellular carcinoma. Thus, an accurate assessment of fibrosis is critical for patient management. Noninvasive tools, including serum biomarkers and imaging techniques, have emerged as practical alternatives to liver biopsy, which presents limitations for invasiveness, cost, and sampling variability.
View Article and Find Full Text PDFCureus
August 2025
Department of Radiation Oncology, University of North Carolina, Chapel Hill, USA.
Background: Integrating a practice-based curriculum to cover essential aspects of patient safety and quality improvement (PSQI) in the outpatient setting can improve resident understanding and engagement in future projects within a radiation oncology residency program.
Objectives: To develop and pilot a workshop-based PSQI curriculum to lead residents through a simulated departmental quality improvement project and enhance understanding regarding tools and metrics used within a PSQI framework.
Methods: This pilot project was completed in the 2023-2024 academic year, with 13 residents in one radiation oncology program.