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Article Abstract
The early removal of drug delivery agents before reaching the affected target remains an area of interest to researchers. Several magnetotactic bacteria (MTB) have been used as self-propelled drug delivery agents, and they can also be controlled by an external magnetic field. By attaching the PEG-biotin polymer, the bacteria are turned into a stealth material that can escape from the phagocytosis process and reach the area of interest with the drug load. In the study, we developed a potential drug carrier by attaching the PEG-biotin to the MTB-through-NHS crosslinker to form a MTB/PEG-biotin complex. The attachment stability, efficacy, and bacterial viability upon attachment of the PEG-biotin polymer were investigated. Biological applications were carried out using a cytotoxicity assay of THP-1 cells, and the results indicate that the MTB/PEG-biotin complex is less harmful to cell viability compared to MTB alone. Along with cytotoxicity, an assay for cell association was also evaluated to assess the complex as a potential stealth material. The development of these complexes focuses on an easy, time-saving, and stable technique of polymer attachment with the bacteria, without damaging the cell's surface, so as to make it a strong and reliable delivery agent.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533374 | PMC |
| http://dx.doi.org/10.3390/biology10100993 | DOI Listing |
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