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http://dx.doi.org/10.1016/j.pathol.2021.08.002 | DOI Listing |
Biomedicines
August 2025
Institute for Medical Research, University of Belgrade, 11000 Belgrade, Serbia.
: The coronavirus disease 2019 (COVID-19) has more severe symptoms and increased mortality among men than women. To address the prognostic impact of vaccination, comorbidities, and inflammatory biomarkers on classified clinical outcomes in hospitalized COVID-19 patients, we compared common and sex differences. : Besides laboratory and clinical parameters at hospital admission, we performed a common and sex-based comparative analysis for the clinical outcomes, RT-qPCR analyses, and measured severe acute respiratory syndrome coronavirus (SARS-CoV-2)-specific IgM and IgG antibody levels of 702 COVID-19 patients in a single centre from June 2020 to April 2022.
View Article and Find Full Text PDFToxicol Lett
August 2025
Department of Radiology and Radiodiagnostics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Jordana 19, Zabrze 41-808, Poland. Electronic address:
Background: The adaptive immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is characterized by the production of various antibodies, with immunoglobulin M (IgM) being the initial isotype synthesized. Lead (Pb), a toxic heavy metal, accumulates in biological systems and disrupts multiple biochemical processes, potentially modulating immune function through alterations in cytokine production and antibody levels.
Objective: This study aimed to elucidate the early immune response to SARS-CoV-2 in lead-exposed individuals by examining antibody profiles and associated immunological parameters.
Hum Vaccin Immunother
December 2025
Department of Clinical Laboratory, State Key Laboratory of Complex, Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Immunity response following vaccination and infection toward the SARS-CoV-2 Omicron variant remains limited in chronic liver disease (CLD) population. This study aims to investigate humoral and cell-mediate immunity to Omicron BA.4/5 among CLD patients with/without breakthrough infections (BI).
View Article and Find Full Text PDFInt J Mol Sci
July 2025
Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090 Vienna, Austria.
Virus-like nanoparticles (VNPs) based on Moloney murine leukemia virus represent a well-established platform for the expression of heterologous molecules such as cytokines, cytokine receptors, peptide MHC (pMHC) and major allergens, but their application for inducing protective anti-viral immunity has remained understudied as of yet. Here, we variably fused the wildtype SARS-CoV-2 spike, its receptor-binding domain (RBD) and nucleocapsid (NC) to the minimal CD16b-GPI anchor acceptor sequence for expression on the surface of VNP. Moreover, a CD16b-GPI-anchored single-chain version of IL-12 was tested for its adjuvanticity.
View Article and Find Full Text PDFHum Vaccin Immunother
December 2025
Department of Laboratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.
China encountered a COVID-19 pandemic shortly after lifting the zero-COVID-19 policy in December 2022. We prospectively investigated the immune responses to SARS-CoV-2 before and after symptom onset of breakthrough infection in individuals vaccinated with inactivated COVID-19 vaccines. Blood samples from 35 vaccinated participants were collected from December 16 to 20, 2022 when they had no symptoms and a second blood sample was collected from each participant from January 4 to 6, 2023.
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