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Retrospective Evaluation of Prognostic Variables and Overall Survival Associated With Nonketotic Hyperosmolar Hyperglycemia in 29 Diabetic Cats (2000-2020).
J Vet Emerg Crit Care (San Antonio)
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University of Minnesota College of Veterinary Medicine, St. Paul, Minnesota, USA.
Objective: To compare survival between cats diagnosed with a nonketotic hyperosmolar hyperglycemic state (HHS) and cats diagnosed with diabetic ketoacidosis (DKA), and to determine whether clinical parameters, clinicopathologic data, and insulin type are associated with survival. Secondary objectives were to evaluate whether these parameters were associated with survival in cats undergoing a generalized hyperglycemic diabetic crisis.
Design: Retrospective evaluation of medical records of cats diagnosed with DKA and HHS between 2000 and 2020.
Ifosfamide-Induced Partial Arginine Vasopressin Resistance Responsive to Vasopressin/Desmopressin and Amiloride.
Cureus
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Internal Medicine, University of Florida College of Medicine, Gainesville, USA.
This is a case of partial arginine vasopressin resistance following the sixth cycle of doxorubicin-ifosfamide-mesna therapy for recurrent spindle cell sarcoma of the thigh. Polyuria and symptomatic hypernatremia started by the second day of the two-day chemotherapy cycle. The diagnosis was confirmed with serum and urine chemistry testing showing urine hypo-osmolality (161 mOsm/kg) with polyuria (4.
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Intensive Care Unit, Mont-Godinne University Hospital, Yvoir, Belgium.
Hyperosmolar hyperglycemic state (HHS) is a life-threatening condition characterized by extreme hyperglycemia, high plasma osmolality, and severe dehydration without significant ketoacidosis. Prompt diagnosis and appropriate management are essential to reduce morbidity and mortality, which range from 10% to 20%. We report a case of a 50-year-old man with insulin-dependent diabetes mellitus secondary to chronic alcoholic pancreatitis presenting with severe HHS and coma.
View Article and Find Full Text PDFAtypical Presentation of New Onset Diabetes with Hyperglycemic Hyperosmolar State in Two Toddlers.
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Section of Pediatric Endocrinology, Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio, United States.
Hyperglycemic hyperosmolar state (HHS), or mixed HHS with diabetic ketoacidosis (DKA), is a rare complication of diabetes in children. Prompt recognition of hyperosmolality is necessary to prevent morbidity and mortality. We report two of the youngest cases with HHS, both presenting at new onset of type 1 diabetes.
View Article and Find Full Text PDFEuglycemic Hyperosmolar Hypernatremic State: A Variant Subtype of Traditional Hyperosmolar Hyperglycemic State With Higher Mortality.
J Emerg Med
May 2025
Hospital Medicine, Department of Internal Medicine, St. Anne's Hospital, Prima CARE, P.C., Fall River, Massachusetts. Electronic address:
Background: Hyperosmolar hyperglycemic state (HHS) is a serious and potentially life-threatening complication of diabetes, defined by serum glucose >600 mg/dL and effective osmolality >320 mOsm/kg. However, some patients present with hyperglycemia (serum glucose levels ≥180 mg/dL but <600 mg/dL), hypernatremia, and effective osmolality >320 mOsm/kg. We refer to this subtype of HHS as euglycemic hyperosmolar hypernatremic state.
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