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The purpose of this paper is to summarize treatment guidelines for the performance of single isocenter LINAC radiosurgery of multiple brain metastases developed and used by 3 experienced centers. This article is not meant to provide consensus guidelines. Rather, this is a practical, "how we do it" reference without substantial discussion. To serve as a treatment reference, the great majority of the information is presented in topic-specific tables.
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http://dx.doi.org/10.1016/j.prro.2021.09.007 | DOI Listing |
Cureus
August 2025
Department of Radiology, Aichi Medical University, Nagakute, JPN.
Background This study was conducted to examine the effects of moving the isocenter (IC) position from the lesion to the center of the brain on stereotactic radiosurgery (SRS) planning with volumetric-modulated arcs (VMA) using the High-Definition Dynamic Radiosurgery (HDRS) platform, a combination of the Agility multileaf collimator (MLC) (Elekta AB, Stockholm, Sweden) and the Monaco planning system (Elekta AB), for single brain metastases (BMs). Methodology The study subject included 36 clinical BMs with the gross tumor volume (GTV) ranging from 0.04 to 48.
View Article and Find Full Text PDFPhys Med Biol
September 2025
Nuclear Research and Development Center, TINT, 9/9, Nakhon Nayok, จ.นครนายก, 26120, THAILAND.
Background: Single-isocenter multiple-target (SIMT) treatments are a robust beam delivery technique involving modulated multileaf collimators for off-axis targets. SIMT requires quality assurance (QA) for both dosimetry and geometry to ensure accurate beam delivery according to the treatment plan. A primary challenge in SIMT QA is the need for phantoms capable of evaluating both dosimetric and geometric accuracy.
View Article and Find Full Text PDFNucl Instrum Methods Phys Res A
March 2025
Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
x-ray fluorescence (XRF) photons induced from gold nanoparticles (GNPs) after being irradiated by an x-ray beam allow for highly sensitive XRF imaging/computed tomography (XFCT) of biological samples containing GNPs at low concentrations on the order of parts-per-million (ppm). The primary goal of this Monte Carlo (MC) study was to investigate the feasibility of upgrading an existing experimental benchtop XRF/XFCT imaging setup adopting a single silicon drift detector (SDD), developed based on the aforementioned concept (often known as XFCT), by deploying another SDD within the same setup. Specifically, an MC model of the original single SDD XFCT setup, along with a filtered 62 kVp polychromatic x-ray beam, was developed using the Geant4 MC toolkit, and added with a second SDD at an equidistance of 11 cm from the isocenter on the opposite side.
View Article and Find Full Text PDFJ Appl Clin Med Phys
September 2025
Department of Radiology, Emory University School of Medicine, Atlanta, Georgia, USA.
Background: Ultra-wide coverage CT (> 128 detector rows) makes it possible to image a heart or brain in a single rotation but are associated with large cone angles, which can severely degrade the image quality.
Purpose: This study evaluate the image quality and artifact levels of a dual-focal-spot single-detector (DFSSD) CT geometry designed to achieve 140 mm z-axis coverage, through a simulation study.
Methods: The DFSSD CT system employs two x-ray focal spots spaced 90 mm apart along the z-axis and a 100 mm CT detector.
J Egypt Natl Canc Inst
September 2025
Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Center, New Delhi, New Delhi, India.
Aim: This study aimed to evaluate the multifaceted clinical utility of the RUBY phantom as a comprehensive quality assurance (QA) platform in high-precision radiotherapy, particularly for stereotactic radiosurgery (SRS) and stereotactic radiotherapy (SRT). The objective was to validate its performance in patient positioning, imaging system accuracy, isocenter congruency, and treatment plan verification across various complex clinical scenarios.
Materials And Methods: A series of QA workflows were conducted using the RUBY phantom and its dedicated modular inserts.