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Background And Design: The coronavirus disease (COVID-19) pandemic is having a devastating effect worldwide. Host genome differences between populations may influence the severity of COVID-19. The Japan COVID-19 Task Force is conducting host genome analysis of hospitalized patients with COVID-19 from more than 70 institutions nationwide in Japan. This report describes the clinical characteristics of patients enrolled to date.
Results: The median (interquartile range) age of the 1674 patients included in the analysis was 59 (45-71) years, and more than half of the patients (66.2%) were male. Less than half of the patients (41.2%) had severe disease. The case fatality rate was 3.2%.
Conclusions: Since this is a hospital-based study, the number of severe cases was relatively high, but the case fatality rate was relatively low, when compared to that of other countries. In the future, we will continue to enroll patients and conduct genome analyses of patients with COVID-19.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8482546 | PMC |
http://dx.doi.org/10.1016/j.ijid.2021.09.070 | DOI Listing |
Comput Biol Med
September 2025
U.O.C. Ematologia e Terapia Cellulare, IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italy.
Artificial intelligence is revolutionizing health care, particularly in precision medicine and noninvasive diagnostics. Anemia, which is a widespread condition that affects billions of people worldwide, compromises oxygen transport due to low hemoglobin levels, which leads to severe complications if left undetected. Early and frequent monitoring is essential, yet traditional blood tests can be invasive, costly, and impractical for continuous assessment.
View Article and Find Full Text PDFJ Surg Educ
September 2025
Atrium Health Wake Forest Baptist Medical Center, Winston Salem, North Carolina.
Objective: The Society of Academic Urologists (SAU) made no definitive recommendation on interview format for the 2025 urology match. The purpose of this study was to survey applicants for this cycle regarding preferences and perceptions related to interview format.
Methods: As part of a prospective assessment, surveys were administered to all applicants to our urology residency program for the 2025 cycle, both before interview and following the match process.
Curr Opin Virol
September 2025
Infection Biology, Global Center for Pathogen and Human Health Research, Cleveland Clinic, Cleveland, OH 44195, USA; Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA. Electronic address:
Intracranial calcifications (ICCs) are a characteristic neuropathological feature of several congenital viral infections, including Zika virus (ZIKV), cytomegalovirus (CMV), and lymphocytic choriomeningitis virus (LCMV). These lesions are linked to severe neurodevelopmental outcomes, such as microcephaly, epilepsy, and cognitive deficits, yet the mechanisms underlying their formation and resolution remain unclear. ICCs are thought to arise from an imbalance in osteogenic and osteolytic signaling in the developing brain.
View Article and Find Full Text PDFJ Public Health (Oxf)
September 2025
Alte University, International School of Medicine, 2 University St, Tbilisi, Georgia, 0177.
Background: Parental vaccine hesitancy (VH) remains a public health concern in Georgia, where misinformation and distrust continue to hinder routine childhood immunization. VH is shaped by psychological, sociocultural, and informational factors, including trust in science, public authorities, and religious institutions. This study examined whether trust-related variables were stronger predictors of VH than traditional sociodemographic characteristics.
View Article and Find Full Text PDFCalcif Tissue Int
September 2025
Department of Endocrinology, Post-Graduate Institute of Medical Education and Research (PGIMER), 001, Nehru Extension Block, Chandigarh, India.
Rare diseases, defined by the 2002 Rare Disease Act, affect fewer than 5 in 10,000 individuals. Rare metabolic bone diseases (MBDs), such as osteogenesis imperfecta, hypophosphatasia, osteopetrosis, and other unclassified disorders, can disrupt bone development and remodeling, posing diagnostic and management challenges. This study analyzed data from the rarembd.
View Article and Find Full Text PDF