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Background: We aimed to study the bilateral choroidal thickness (CT) symmetry and difference in uncomplicated pachychoroid subjects using wide-field swept-source optical coherence tomography (SS-OCT).
Methods: All subjects underwent a wide-field 16-mm one-line scan using SS-OCT. Bilateral CT was measured at, and compared among, the following 12 points: three points at 900-µm intervals from the nasal optic disc margin (nasal peripapillary area), one point at the subfovea, six points at 900-µm intervals from the fovea to the nasal and temporal areas (macular area), and two peripheral points 5400 and 8100 µm from the fovea (peripheral area).
Results: There were no statistically significant differences in CT between the right and left eyes in any area (all > 0.05); they all showed significant positive correlations (all < 0.01). However, the correlation coefficients (ρ) were smaller for the nasal peripapillary and peripheral areas compared to the macular area.
Conclusions: The CTs in each region were bilaterally symmetrical in subjects with uncomplicated pachychoroid. However, interocular difference in CT increased from the center to the periphery, indicating that the anatomical variation of the nasal peripapillary and peripheral choroid was greater than that of the macula.
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http://dx.doi.org/10.3390/jcm10184253 | DOI Listing |
Eur J Ophthalmol
September 2025
Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
PurposeThe pachychoroid disease spectrum is characterized by choroidal thickening, vascular hyperpermeability, and structural alterations in the choroidal circulation. This can lead to central serous chorioretinopathy (CSC), which is clinically seen as retinal pigment epithelium detachments and subretinal fluid accumulation. Despite the fact that corticosteroid exposure is a main risk factor for CSC, its pathogenesis is unknown.
View Article and Find Full Text PDFRetina
March 2025
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Purpose: To report the 1-year progression rate and associated risk factors in an Asian cohort of patients with pachychoroid disease spectrum phenotype.
Methods: The authors report the 1-year findings from a prospective observational study, recruiting subjects with subfoveal choroidal thickness of ≥300 µm. Each eye was evaluated at baseline and at month 12 according to a standardized protocol including visual acuity and multimodal imaging.
Sci Rep
January 2025
The Department of Ophthalmology, General Hospital of Central Theater Command, No. 627 Wuluo Road, Wuchang District, Wuhan, 430000, Hubei, China.
This study used ultra-widefield swept-source optical coherence tomography angiography (UWF SS-OCTA) to analyze and compare choroidal blood flow and anatomical changes in eyes affected by central serous chorioretinopathy (CSC), pachychoroid neovasculopathy (PNV), and uncomplicated pachychoroid (UCP). The findings revealed distribution patterns of vortex veins across the three patient groups and provided initial findings insights into the origin of choroidal neovascularization (CNV) in PNV. A total of 44 patients with CSC, 38 with PNV, and 46 with UCP were included in the analysis.
View Article and Find Full Text PDFInvest Ophthalmol Vis Sci
August 2023
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.
Purpose: The purpose of this study was to investigate choroidal vein (ChV) morphological features in pachychoroid disease (PCD) with choroidal vascular hyperpermeability (CVH).
Methods: This retrospective study assessed subfoveal choroidal thickness (SFCT) and CVH area numbers and locations of recruited patients with PCD using multimodal images. ChV alteration patterns, including fusiform, bulbosity, sausaging, confluence, and anastomoses, as well as asymmetric ChVs, dominant ChVs, and non-dominant ChVs, were evaluated using wide-field indocyanine green angiograms.
Br J Ophthalmol
May 2023
Retina Research Group, Singapore Eye Research Institute, Singapore
Aim: To describe the clinical characteristics in a cohort of patients with the pachychoroid phenotype and to evaluate the association of ocular and systemic factors with type of complications observed.
Methods: We report baseline findings from a prospective observational study which recruited subjects with subfoveal choroidal thickness (SFCT) of ≥300 µm on spectral-domain optical coherence tomography (OCT). Multimodal imaging was used to classify eyes as uncomplicated pachychoroid (UP) or pachychoroid disease with pachychoroid pigment epitheliopathy (PPE), central serous chorioretinopathy (CSC) or pachychoroid neovasculopathy (PNV) subtypes.