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http://dx.doi.org/10.1002/hep4.1816 | DOI Listing |
J Hazard Mater
September 2025
Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Shuangqing RD 18, Beijing 100085, China; University of Chinese Academy of Sciences, Yuquan RD 19 a, Beijing 100049, China. Electronic address:
Epoxiconazole (EPX) is widely applied to control various fungal diseases in crops. However, the toxicological effects of EPX on reptiles remain unknown, especially at the enantiomer level. In this study, lizards were repeatedly exposed to rac-EPX, (+)-EPX, and (-)-EPX at doses of 10 and 100 mg/kg bw for 21 days.
View Article and Find Full Text PDFAgeing Res Rev
September 2025
Interdisciplinary Neuroscience Program, Syracuse University, Syracuse, NY 13244, USA; Department of Biomedical and Chemical Engineering, Syracuse University, Syracuse, NY 13244, USA.
Body-brain interaction (BBI) plays a critical role in coordinating the communication between peripheral organs and the brain, contributing to the comorbidity of metabolic disorders and neurological disorders. In the context of obesity, one of the key mediators driving systemic and neuroinflammatory responses is the soluble form of tumor necrosis factor (TNF), which primarily signals through TNF receptor 1 (TNFR1) to regulate inflammation and cell death. In this review, we examine how TNF/TNFR1-mediated metabolic inflammation in obesity disrupts cellular homeostasis across multiple organ systems, including the brain.
View Article and Find Full Text PDFInt J Biometeorol
September 2025
Department of Pharmaceutical and Life Sciences, Jiujiang University, Jiujiang, 332005, People's Republic of China.
Climate change, characterized by rising global temperatures, has resulted in increased instances of heatwaves, posing significant public health threats. Among various health risks, heat-related illnesses are prevalent, exacerbated by environmental factors like high humidity and high-fat diet (HFD), which are known to impact metabolic functions in animals. The study was conducted to evaluate the effects of heat and humidity stress on liver function markers and histological changes in rats fed a high fat diet, thereby enhancing our understanding of how environmental stressors impact liver health.
View Article and Find Full Text PDFJ Vet Diagn Invest
August 2025
Laboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan.
A 6-y-old, spayed female, mixed-breed cat developed anorexia, weight loss, and watery diarrhea, and later died. Elevated liver enzyme activities and mild anemia were present antemortem. Generalized jaundice and a diffusely yellow liver with dark-red foci were noted at postmortem examination.
View Article and Find Full Text PDFSci Rep
August 2025
Department of Pharmacology, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan, 24100, Turkey.
The objective of this study was to elucidate the impact of D-(-)-Quinic acid (D-(-)-QA), a natural phenolic acid, on the molecular mechanisms of inflammation and oxidative stress in brain and liver damage in thioacetamide (TAA)-induced hepatic encephalopathy (HE) in rats. To establish an experimental HE model, rats were injected with three doses (200 mg/kg, intraperitoneally) of TAA every other day, followed by the administration of D-(-)- QA (200 or 400 mg/kg, orally) for fourteen days. Serum ammonia, alanine transaminase (ALT), and aspartate transaminase (AST) levels were detected.
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