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Stability at the stance phase and near normal able-bodied swing phase kinematics are essential in designing the prosthetic knee mechanism for transfemoral amputees. Primarily, insufficient mid swing toe clearance results in asymmetrical gait patterns, leading to muscular-skeletal pain and joint degeneration. The present work is focused on synthesizing a polycentric knee mechanism to enhance the toe-clearance at mid-swing for safe level ground walking of amputees in developing countries. Both fixed and moving centrodes of the four-bar knee mechanism are considered in optimal synthesis of the mechanism for achieving able-bodied gait patterns using evolutionary algorithms in mechanism design software tools. The knee stability at heel contact, stabilizing moment at push-off, stable knee flexion range, maximum knee flexion and maximum toe-clearance at mid-swing are the parameters used for comparing the knee design with the existing commercially available designs. The optimized results are then verified experimentally by building a functional prototype using a 3 D printing technique. The designed mechanism executes nominal performance in four parameters and offers enhanced toe-clearance during mid-swing. This is a significant improvement over the existing designs for amputees to navigate comfortably on irregular terrain in developing countries.
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http://dx.doi.org/10.1080/10255842.2021.1972291 | DOI Listing |
Int J Surg
September 2025
Department of Anesthesiology, Qingdao Municipal Hospital, Qingdao, Shandong Province, China.
Background: As a common postoperative neurological complication, postoperative delirium (POD) can lead to poor postoperative recovery in patients, prolonged hospitalization, and even increased mortality. However, POD's mechanism remains undefined and there are no reliable molecular markers of POD to date. The present work examined the associations of cerebrospinal fluid (CSF) sTREM2 with CSF POD biomarkers, and investigated whether the effects of CSF sTREM2 on POD were modulated by the core pathological indexes of POD (Aβ42, tau, and ptau).
View Article and Find Full Text PDFRev Bras Ortop (Sao Paulo)
June 2025
Grupo do Quadril, Departamento de Ortopedia e Traumatologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil.
Injuries to the proximal hamstring muscle complex are common in athletes and range from strains to tendinous and bony avulsions. The lesion mechanism typically involves an eccentric contraction of the hamstring muscles during abrupt hip hyperflexion with the knee in extension. Low-speed injuries occur in high kicks and splits, whereas tendon avulsions are common in high-speed activities, such as running and ballet.
View Article and Find Full Text PDFRev Bras Ortop (Sao Paulo)
June 2025
Hip Group, Department of Orthopedics and Traumatology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Injuries to the proximal hamstring muscle complex are common in athletes and range from strains to tendinous and bony avulsions. The lesion mechanism typically involves an eccentric contraction of the hamstring muscles during abrupt hip hyperflexion with the knee in extension. Low-speed injuries occur in high kicks and splits, whereas tendon avulsions are common in high-speed activities, such as running and ballet.
View Article and Find Full Text PDFAnesth Analg
September 2025
From the Department of Anesthesiology.
Background: Total knee arthroplasty (TKA) is a surgical procedure that induces intense acute postoperative pain, but the mechanisms that amplify post-TKA pain remain incompletely understood. Endocannabinoids, such as 2-arachidonoylglycerol (2-AG), are endogenous lipids that can produce antinociceptive effects. However, hydrolysis of 2-AG by monoacylglycerol lipase (MAGL) generates arachidonic acid, the precursor to a host of eicosanoids that enhance pain.
View Article and Find Full Text PDFJ Surg Oncol
September 2025
Orthopedic Oncology Service, Department of Orthopedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Background: Hemicondylar fresh frozen allografts address partial knee defects while preserving native anatomy and bone stock. This study evaluated long-term survival, failure modes, and functional outcomes following hemicondylar reconstruction.
Methods: We conducted a retrospective analysis of hemicondylar fresh frozen allograft reconstructions.