Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
During brain development, neural precursor cells (NPCs) in different brain regions produce different types of neurons, and each of these regions plays a different role in the adult brain. Therefore, precise regionalization is essential in the early stages of brain development, and irregular regionalization has been proposed as the cause of neurodevelopmental disorders. The mechanisms underlying brain regionalization have been well studied in terms of morphogen-induced expression of critical transcription factors for regionalization. NPC potential in different brain regions is defined by chromatin structures that regulate the plasticity of gene expression. Herein, we present recent findings on the importance of chromatin structure in brain regionalization, particularly with respect to its regulation by Polycomb-group proteins and chromatin accessibility.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/bies.202100155 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Development of the SCI-BodyMap-Measuring Mental Body Representations in Adults With Spinal Cord Injury: Protocol for Item Generation, Reliability, and Validity Testing.
JMIR Res Protoc
September 2025
Division of Physical Therapy and Rehabilitation Science, Department of Family Medicine and Community Health, Medical School, University of Minnesota-Twin Cities, Minneapolis, MN, United States.
Background: Approximately 69% of Americans with spinal cord injury (SCI) have neuropathic pain. Research suggests that impairments in mental body representations (MBRs; ie, representations of the body in the brain) likely contribute to neuropathic pain. Clinical trials in adults with SCI, focused on restoring MBR, led to improvements in sensation and movement as well as neuropathic pain relief.
View Article and Find Full Text PDFDistinct prelimbic cortex ensembles encode response execution and inhibition.
Proc Natl Acad Sci U S A
September 2025
Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224.
Learning when to initiate or withhold actions is essential for survival, requiring the integration of past experiences with new information to adapt to changing environments. The prelimbic cortex (PL) plays a central role in this process, with a stable PL neuronal population (ensemble) recruited during operant reward learning to encode response execution. However, it is unknown how this established reward-learning ensemble adapts to changing reward contingencies, such as reward omission during extinction.
View Article and Find Full Text PDFBlood flow in the human cerebral cortex: Large-scale pial vascularization and 1D simulation.
PLoS Comput Biol
September 2025
Department of Mathematical and Computational Methods, National Laboratory for Scientific Computing, Petrópolis, Brazil.
Understanding cerebral circulation is crucial for early diagnosis and patient-oriented therapies for brain conditions. However, blood flow simulations at the organ scale have been limited. This work introduces a framework for modeling extensive vascular networks in the human cerebral cortex and conducting pulsatile blood flow simulations.
View Article and Find Full Text PDFMulti-modal virtual reality system for tinnitus treatment methods and validation.
PLoS One
September 2025
Department of Otorhinolaryngology-Head and Neck Surgery, Ansan Hospital, Korea University College of Medicine, Ansan, Republic of Korea.
Virtual reality (VR) has been utilized in clinical treatment because it can efficiently simulate situations that are difficult to control in the real world. In this study, we evaluated the efficacy of VR in patients with chronic subjective tinnitus. We assessed the clinical effectiveness based on electroencephalogram (EEG) analysis and questionnaire responses after patients participated in a 6-8-week VR-based tinnitus relief program.
View Article and Find Full Text PDFPresynaptic and postsynaptic determinants of claustro-cortical connectivity.
Curr Biol
July 2025
Department of Neuroscience, Karolinska Institutet, 17177 Stockholm, Sweden. Electronic address:
The claustrum (CLA) is a thin and elongated brain structure that is located between the insula and lateral striatum and is implicated in a wide range of behaviors. It is characterized by its extensive synaptic connectivity with multiple cortical regions. While CLA projection neurons are glutamatergic, several studies have shown an inhibitory impact of CLA on its cortical targets, suggesting the involvement of inhibitory cortical interneurons.
View Article and Find Full Text PDF