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N-heterocyclic carbene (NHC) metal complexes have gained an incredible amount of attention in the course of the last two decades and have become indispensable as an intricate part of a plethora of applications. The areas of their synthesis and derivatization are constantly evolving and bring new, more sustainable, cost-effective and simpler approaches to the design of existing and next generation catalysts and materials. This article provides an overview of the latest developments, focusing on those which have appeared during the last two years.
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http://dx.doi.org/10.1039/d1dt01847g | DOI Listing |
Drug Dev Res
September 2025
Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin, P. R. China.
The structural modification and derivatization of natural products represent an essential pathway for pharmaceutical innovation in the management of depression. The 8-phenyl tetrahydroisoquinoline, as a parent core, was obtained from magnoflorine by a structural simplification strategy. The present report details the synthesis and antidepressant activity studies of 8-phenyl-THIQ analogs.
View Article and Find Full Text PDFOrg Lett
September 2025
School of Chemical Sciences, National Institute of Science Education and Research (NISER), An OCC of Homi Bhabha National Institute, Bhubaneswar 752050, India.
A manganese(II)-catalyzed anti-Markovnikov addition of diarylphosphine oxides to primary and secondary allylic alcohols has been developed, which delivered synthetically valuable γ-hydroxy phosphine oxides. The reaction proceeds under mild, base-assisted conditions with a broad substrate scope and excellent functional group tolerance. Mechanistic studies indicate the involvement of a homogeneous catalytic system and a radical pathway.
View Article and Find Full Text PDFOrg Lett
September 2025
Departamento de Química Orgánica e Inorgánica and Instituto Universitario de Química Organometálica "Enrique Moles", Universidad de Oviedo, Julian Clavería 8, 33006 Oviedo, Spain.
The gold(I)-catalyzed cycloisomerization of aliphatic 1-bromoalkynes has been applied to the synthesis of heterospirocycles. The reactivity of the C(sp)-Br bond in the products allowed for further derivatization of the obtained scaffolds. In this way, spiroheterocycles decorated with a plethora of functional groups (i.
View Article and Find Full Text PDFChem Commun (Camb)
September 2025
Department of Chemistry, School of Chemistry, Xi'an Key Laboratory of Sustainable Energy Material Chemistry and Engineering Research Center of Energy Storage Materials and Devices, Ministry of Education, Xi'an Jiaotong University, Xi'an 710049, China.
A copper-catalyzed 1,4-alkylcyanation of CF-containing 1,3-enynes with bicyclic hydroperoxides and TMSCN is described. In this cascade, the alkyl source originates from selective cleavage of a C-C bond in the fused bicyclic skeletons, enabling the successful introduction of a succinimide fragment into tetrasubstituted allenes. This reaction is characterized by mild conditions, broad substrate scope, excellent functional group tolerance, and ease of large-scale synthesis and product derivatization.
View Article and Find Full Text PDFOrg Lett
September 2025
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan 650500, P. R. China.
An iron(III)-catalyzed methanesulfonic-acid-mediated [3 + 2 + 1C] annulation of enaminones assembling a 1,2-dihydropyridine (1,2-DHP) scaffold has been developed for the first time. This approach facilitates the rapid synthesis of 2-hydroxy-1,2-DHP derivatives in moderate to excellent yields with a broad substrate scope under mild conditions. The employment of 1,3-dioxolane as both a 1C synthon and solvent enables simultaneous incorporation of both a carbon atom and a hydroxy group into 1,2-DHPs.
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