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Pelvic floor dysfunction symptoms and knowledge level and quality of life in systemic sclerosis women.
Women Health
September 2025
Nezahat Keleşoğlu Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Necmettin Erbakan University, Konya, Turkey.
This study compared the pelvic floor dysfunction (PFD) symptoms, knowledge level and quality of life inwomen with systemic sclerosis (SSc) and healthy. The study included 30 SSc and 30 healthy women. The presence and severity of PFD symptoms were evaluated using the Pelvic Floor Distress Inventory-20 (PFDI-20) (Subscales: Pelvic Organ Prolapse Distress Inventory-6 (POPDI-6), Colorectal-Anal Distress Inventory-8 (CRADI-8), and Urinary Distress Inventory-6 (UDI-6)).
View Article and Find Full Text PDFLumbo-pelvic-hip complex strengthening with and without isolated pelvic floor muscle training for postpartum pelvic floor health: a systematic review and meta-analysis.
J Sci Med Sport
August 2025
Sports Performance, Recovery, Injury and New Technologies Research Centre, Australian Catholic University, Australia; School of Behavioural and Health Sciences, Australian Catholic University, Brisbane, Australia.
Objectives: This systematic review and meta-analysis examined the effectiveness of lumbo-pelvic-hip complex strengthening and/or stabilisation exercises, with and without isolated pelvic floor muscle training, on postpartum pelvic floor health. Specifically, effects on pelvic floor muscle strength, endurance, activity, and pelvic floor dysfunction symptom severity were analysed.
Design: A systematic review and meta-analysis of randomised controlled trials was conducted.
Pelvic floor physical therapy: Enhancing patient outcomes.
JAAPA
September 2025
At the time this article was written, Mollie Francis, Michaela Thielen, and Cailin Austin were PA students at Mayo Clinic in Rochester, MN. Now, Mollie Francis works as a hospitalist PA at Regions Hospital in St. Paul, MN; Michaela Thielen as a dermatology PA at OakLeaf Clinics Dermatology in Chippe
Pelvic floor disorders are a wide-ranging group of conditions arising due to abnormalities of the musculature of the pelvic floor. These conditions can include constipation, pelvic pain, urinary incontinence, and dyspareunia. This article first provides an overview of key anatomy of the pelvic floor muscles before discussing pelvic floor physical therapy (PFPT), highlighting the goals of treatment and tactics used by physical therapists to achieve these goals.
View Article and Find Full Text PDFTurkish Translation and Cross-Cultural Adaptation of the Pelvic Floor Dysfunction-SENTINEL Screening Tool: A Methodological Study.
Int Urogynecol J
September 2025
Health Sciences Faculty, Department of Physiotherapy and Rehabilitation, Izmir Katip Celebi University, Izmir, Türkiye.
Introduction And Hypothesis: To translate and perform cultural adaptation of the Pelvic Floor Dysfunction-SENTINEL (PFD-SENTINEL) screening tool into Turkish and to establish its reliability and validity for female athletes.
Methods: The study included 200 female athletes (mean age 22 ± 4 years). The translation of the PFD-SENTINEL, which comprised the symptoms related to PFD and item sections related to general risk factors and sports-related risk factors, was performed in accordance with international recommendations.
KDM4A-induced tumor senescence enhances the efficacy of immunotherapy by inhibiting AGT-PHB1 axis-mediated mitophagy in colorectal cancer.
Autophagy
September 2025
Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Immune checkpoint inhibitors (ICIs) can re-active the immune response and induce a complete response in mismatch repair-deficient and microsatellite instability-high (dMMR/MSI-H) colorectal cancer (CRC). However, most CRCs exhibit proficient mismatch repair and microsatellite stable (pMMR/MSS) phenotypes with limited immunotherapy response because of sparse intratumoral CD8 T-lymphocyte infiltration. Cellular senescence has been reported to involve immune cell infiltration through a senescence-associated secretory phenotype (SASP).
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