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http://dx.doi.org/10.1177/02692163211041999 | DOI Listing |
Genet Med
September 2025
Institute for Clinical and Translational Science, University of California, Irvine, CA, USA.
Purpose: Advancements in sequencing technologies have significantly improved clinical genetic testing, yet the diagnostic yield remains around 30-40%. Emerging technologies are now being deployed to address the remaining diagnostic gap.
Methods: We tested whether short-read genome sequencing could increase the diagnostic yield in individuals enrolled into the UCI-GREGoR research study, who had suspected Mendelian conditions and prior inconclusive testing.
BMC Public Health
September 2025
Department of Dermatology and Allergy, TUM School of Medicine and Health, Technical University of Munich, Biedersteiner Str. 29, 80802, Munich, Germany.
Background: Psoriasis, a chronic inflammatory skin disorder, imposes a high burden on those affected, often leading to stigma and increased depression risk. With the increasing importance of digital media in medical contexts, there is a notable prevalence of misinformation and low-quality content. This study aims to explore the experiences of individuals affected by psoriasis regarding their disease-related digital media use.
View Article and Find Full Text PDFBMC Ecol Evol
September 2025
Lehrstuhl für Zoologie, TUM School of Life Sciences, Technical University of Munich, Liesel-Beckmann Strasse 4, Freising, 85354, Germany.
Accurate three-dimensional localisation of ultrasonic bat calls is essential for advancing behavioural and ecological research. I present a comprehensive, open-source simulation framework-Array WAH-for designing, evaluating, and optimising microphone arrays tailored to bioacoustic tracking. The tool incorporates biologically realistic signal generation, frequency-dependent propagation, and advanced Time Difference of Arrival (TDoA) localisation algorithms, enabling precise quantification of both positional and angular accuracy.
View Article and Find Full Text PDFCurr Med Res Opin
September 2025
International Society for Medical Publication Professionals (ISMPP), Tarrytown, NY, USA.
Patient engagement (PE) has evolved from an emerging concept to a fundamental ethos underpinning healthcare research and communication. In this commentary, we explore the historical evolution in medical research from patients being participants in clinical trials to becoming integral partners in communicating medical research findings. The progression from "why" to "how" PE should occur represents a fundamental shift in the medical publication landscape.
View Article and Find Full Text PDFLancet Planet Health
September 2025
Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa.
Rift Valley fever (RVF), a zoonotic mosquito-borne viral disease with erratic occurrence and complex epidemiology, results in substantial costs to veterinary and public health and national economies. Since 1985, RVF virus (RVFV) epidemiology has focused on epidemics triggered by flood-induced emergence of transovarially infected mosquitoes, following an interepidemic period during which RVFV persists primarily in floodwater Aedes spp mosquito eggs, with potential for low-level interepidemic circulation. In this Personal View, we challenge this classic framework of RVFV epidemiology, presenting instead a spectrum of RVFV dynamics ranging from epidemic to hyperendemic.
View Article and Find Full Text PDF