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http://dx.doi.org/10.3389/fphar.2021.732622 | DOI Listing |
J Plast Reconstr Aesthet Surg
September 2025
Leeds Breast & Cosmetic Clinic, The Leeds Nuffield Hospital, 2 Leighton Street, Leeds, UK. Electronic address:
J Immunother Cancer
September 2025
Pharmaceutical Sciences, Washington State University, Spokane, Washington, USA
Prostate cancer (PC) is notoriously known for exhibiting an immunologically cold phenotype in the tumor immune microenvironment (TIME), leading to the need for interventions to enhance immunotherapy efficacy. Recent findings by Zhao in the identified stromal monoamine oxidase A (MAOA), a key enzyme that degrades monoamine neurotransmitters and plays a role in the neuroendocrine system, as a critical regulator of the immune response to PC. Altering MAOA levels in myofibroblastic cancer-associated fibroblasts, either genetically or pharmacologically, can reprogram PC's TIME to modulate CD8 T cell-mediated cytotoxicity through the WNT5A-Ca²-NFATC1 signaling axis, highlighting the stromal influences on CD8 T cell cytotoxic activity within the TIME.
View Article and Find Full Text PDFInt J Surg
September 2025
Department of Neurosurgery, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China.
Curr Med Res Opin
September 2025
International Society for Medical Publication Professionals (ISMPP), Tarrytown, NY, USA.
Patient engagement (PE) has evolved from an emerging concept to a fundamental ethos underpinning healthcare research and communication. In this commentary, we explore the historical evolution in medical research from patients being participants in clinical trials to becoming integral partners in communicating medical research findings. The progression from "why" to "how" PE should occur represents a fundamental shift in the medical publication landscape.
View Article and Find Full Text PDF