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Article Abstract
The nucleoside antibiotic angustmycin, produced by some Streptomyces strains, is composed of adenine and C sugar and shows antibiotic and antitumor activities. In this study, we propose a biosynthetic pathway for angustmycin using a heterologous expression experiment coupled with in silico analysis of the angustmycin biosynthetic gene (agm) cluster. The biochemical characterization of Agm6 demonstrated its role in angustmycin biosynthesis as an unprecedented dehydratase.
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| http://dx.doi.org/10.1038/s41429-021-00466-7 | DOI Listing |
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