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http://dx.doi.org/10.1177/1744987119881060 | DOI Listing |
J Allergy Clin Immunol Pract
September 2025
Associate Professor of Medicine, Medical Director of Clinical Asthma Research, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center. Electronic address:
Asthma and allergic diseases are heterogeneous conditions driven by complex immunological pathways, with type 2 (T2) inflammation being a key but not exclusive component. Advances in immunology have spurred interest in a breadth of mechanisms and innovative therapeutic strategies, including novel targets, extended dosing intervals, and combined-target therapies. This clinical commentary provides a critical overview of ongoing clinical trials and emerging evidence supporting the use of these therapies in asthma and other allergic conditions.
View Article and Find Full Text PDFAAPS J
September 2025
Precision Medicine Bioanalytical & Translational Sciences, Bristol Myers Squibb, Route 206 & Province Line Road, Princeton, NJ, 08543, USA.
CAR-T-cells can drive MHC class-I-mediated CD8 + cytotoxic T-cell response towards CAR constructs in addition to an antibody response. Immune response may also develop towards residuals present in the CAR-T cell product such as AAV, CRISPR/CAS9, and expamers. Health authorities recommend developing assays to assess both humoral and cellular immunogenicity towards the CAR-T protein.
View Article and Find Full Text PDFAm J Hum Biol
September 2025
University of Utah, Salt Lake City, USA.
This commentary on Growth Rates and Life Histories in Twenty-Two Small-Scale Societies overviews the original publication and its contributions, and reviews advances in the field of human growth and development since its publication.
View Article and Find Full Text PDFInt Psychogeriatr
August 2025
Research Center in Spirituality and Health (NUPES), School of Medicine, Federal University of Juiz de Fora (UFJF), Brazil. Electronic address:
Humanity is undergoing a profound demographic transition, with older adults representing a growing share of society. This late stage of life not only prompts profound reflections on the meaning of life and the inevitability of death, but is also associated with a higher occurrence of certain non-ordinary experiences - such as end-of-life experiences (ELEs), after-death communications (ADCs), and near-death experiences (NDEs). These experiences evoke deeper questions about death itself, the nature of dying, and the essence of who we are.
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