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Timely excision of prophage Φ13 is essential for the infectious process.
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Department of Microbiology, Biology of Gram-Positive Pathogens Unit, Institut Pasteur, Université Paris Cité, CNRS UMR2001, Paris, France.
Mobile genetic elements play an essential part in the infectious process of major pathogens, yet the role of prophage dynamics in pathogenesis is still not well understood. Here, we studied the impact of the Φ13 converting prophage, whose integration inactivates the β-toxin gene, on staphylococcal pathogenesis. We showed that prophage Φ13 is lost in approximately half the bacterial population during the course of infection.
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National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Staphylococcal enterotoxin-like W (SElW) is a novel, widely prevalent enterotoxin-like protein that functions as a classical staphylococcal superantigen (SAg) and has been shown to exacerbate infections caused by the epidemic clone CC398. However, the genetic distribution and amino acid polymorphisms, biological and antitumor activity, and T cell receptor (TCR) binding sites of SElW in strains prevalent in China have not been investigated. The carrier rate and distribution of were determined by PCR, the stability and antitumor activity of recombinant SElW (rSElW) protein were evaluated.
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State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Beijing, 100071, China.
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Department of Pediatrics, Soonchunhyang University Gumi Hospital, Gumi, South Korea; Department of Pediatrics, National Jewish Health, Denver, CO, USA. Electronic address:
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Toxic shock syndrome (TSS) is a serious, often fatal disease, rarely occurring in dogs via infection with and . The development of TSS is mainly dependent on the presence of bacterial toxins recognized to be potent superantigens causing the release of massive amounts of host inflammatory cytokines, notably TNF-α, progressing to high fever, hypotension, haemoconcentration, thrombosis and neutrophil and endothelial activation with multiple organ failure. Rarely, TSS is associated with erythematous and exfoliative dermatitis progressing to ulceration with extremely extensive dermo-epidermal detachment, which is often very painful.
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