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Article Abstract
We herein report an asymmetric protocol to access a series of orthogonally functionalized acyclic chiral target molecules containing a quaternary stereogenic center by carrying out the enantioselective α-alkylation of novel orthogonally functionalized dioxolane-containing cyanoacetates under chiral ammonium salt catalysis. By using just 1 mol % of Maruoka's spirocyclic ammonium salt catalysts enantioselectivities up to e.r.=97.5 : 2.5 could be achieved and further functional group manipulations of the products were carried out as well.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8340069 | PMC |
| http://dx.doi.org/10.1002/open.202100162 | DOI Listing |
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