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http://dx.doi.org/10.1111/epi.17030 | DOI Listing |
JAMA Psychiatry
September 2025
Denovo Biopharma LLC, San Diego, California.
Importance: This study represents a first successful use of a genetic biomarker to select potential responders in a prospective study in psychiatry. Liafensine, a triple reuptake inhibitor, may become a new precision medicine for treatment-resistant depression (TRD), a major unmet medical need.
Objective: To determine whether ANK3-positive patients with TRD benefit from a 1-mg and/or 2-mg daily oral dose of liafensine, compared with placebo, in a clinical trial.
JAMA Netw Open
September 2025
Division of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla.
Importance: Janus kinase (JAK) inhibitors are highly effective medications for several immune-mediated inflammatory diseases (IMIDs). However, safety concerns have led to regulatory restrictions.
Objective: To compare the risk of adverse events with JAK inhibitors vs tumor necrosis factor (TNF) antagonists in patients with IMIDs in head-to-head comparative effectiveness studies.
JAMA Netw Open
September 2025
Social and Behavioral Sciences Branch, Division of Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland.
Importance: Higher intellectual abilities have been associated with lower mortality risk in several longitudinal cohort studies. However, these studies did not fully account for early life contextual factors or test whether the beneficial associations between higher neurocognitive functioning and mortality extend to children exposed to early adversity.
Objective: To explore how the associations of child neurocognition with mortality changed according to the patterns of adversity children experienced.
Genetica
September 2025
Faculty of Fisheries and Aquaculture Sciences, Universiti Malaysia Terengganu, Kuala Nerus, Terengganu, Malaysia.
Population genetics plays a critical role in creating policies for managing fisheries, conservation, and development of aquaculture. The golden snapper, Lutjanus johnii (Bloch, 1792), is a highly commercial and aquaculture important snapper species. This study used mitochondrial markers D-loop (151 specimens) and Cytochrome b (Cyt-b, 120 specimens) from 10 populations, including populations from the east South China Sea, the west South China Sea and the Strait of Malacca to investigate the genetic diversity, population connectivity, and historical demography of L.
View Article and Find Full Text PDFInfection
September 2025
Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre, Hvidovre, Denmark.
Purpose: To investigate bacteriology, antibiotic treatment and adverse birth outcomes (ABOs) in pregnancies with and without bacteriuria and urinary tract infections (UTIs) based on urine cultures and clinical diagnoses.
Methods: Registry-based cohort study.
Population: Pregnancies with at least one urine culture analysed at one of two hospitals in the Capital Region, Denmark, between 2015 and 2021.