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We present two cases of failure of balloon inflation secondary to balloon separation from the delivery catheter when implanting the SAPIEN 3 transcatheter heart valve (Edwards Lifesciences, Irvine, CA, USA). Although very uncommon, this is a potentially disastrous complication of transcatheter intervention. Case 1 highlights the complexity of the problem when it occurs and subsequent complications. Case 2 highlights how to manage this issue successfully.
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http://dx.doi.org/10.1016/j.carrev.2021.07.025 | DOI Listing |
Struct Heart
September 2025
Division of Cardiology and Cardiac Surgery, McMaster University and Hamilton Health Sciences, Hamilton, Canada.
Background: The computed tomography selection of patients with bicuspid aortic stenosis for treatment with balloon-expandable valve (BEV) transcatheter aortic valve replacement (TAVR) is uncertain. We therefore evaluated a novel sizing algorithm for SAPIEN 3 BEV.
Methods: A prospective single-center registry from February 2020 to May 2024 including patients with bicuspid aortic stenosis treated with TAVR (and surgical aortic valve replacement starting in September 2022).
Eur Heart J Case Rep
August 2025
Division of Cardiovascular Medicine, Nouvel Hôpital Civil, Strasbourg University Hospital, BP 426, Strasbourg 67091, France.
Background: The number of transcatheter aortic valve replacement (TAVR) procedures is steadily increasing, and although its main complications are well documented, ventricular arrhythmias (VAs) following TAVR remain infrequently reported in the literature. We present a rare case of ventricular tachycardia (VT) occurring late after TAVR, originating from the lower portion of the prosthesis at the interventricular septum.
Case Summary: An 82-year-old Caucasian man presented with recurrent episodes of lipothymia and VT occurring late after undergoing TAVR.
Am J Cardiol
August 2025
Department of Cardiac, Thoracic, and Vascular Sciences and Public Health, University of Padua, Italy. Electronic address:
Mitral annular calcification (MAC) related mitral stenosis (MS) presents a significant therapeutic challenge, especially in patients considered high-risk or inoperable.Transcatheter mitral valve replacement (TMVR) has emerged as an alternative, but the procedure remains technically demanding due to anatomical complexities and the risk of complications. We report the case of a 72 year-old man with severe MAC and MS, who successfully underwent TMVR using a 29 mm Edwards Sapien 3 valve.
View Article and Find Full Text PDFEur Heart J Cardiovasc Imaging
August 2025
Centre for Cardiovascular Medicine and Devices, William Harvey Research Institute, Queen Mary University of London and Barts Heart Centre, London, UK.
Introduction: Several factors, including device design, annulus size, and sizing strategies, influence transcatheter heart valve (THV) hemodynamic outcomes in patients with aortic stenosis(AS). This substudy evaluates early (30-day) echocardiographic outcomes of the Myval, Sapien, and Evolut THV series, focusing on hemodynamic performance and valve durability.
Methodology: The LANDMARK trial is a prospective, randomised, multicentre, open-label, non-inferiority trial comparing 384 patients implanted with Myval THV series to 384 receiving Sapien and Evolut THV series.
JACC Cardiovasc Interv
August 2025
Division of Cardiothoracic Surgery, Washington University in St. Louis, St. Louis, Missouri, USA.
Background: Aortic valve-in-valve (AViV) replacement for is approved for patients with degenerated surgical valves at high or prohibitive surgical risk, mostly on the basis of small series with short-term follow-up.
Objectives: The aim of this study was to analyze the outcomes of AViV therapy using contemporary balloon-expandable valves (BEVs) in a large series with mid-term outcomes.
Methods: BEV AViV patients (June 2015 to December 2023) in the Society for Thoracic Surgeons (STS)/American College of Cardiology TVT (Transcatheter Valve Therapy) Registry were propensity matched to native transcatheter aortic valve replacement (TAVR) patients.