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http://dx.doi.org/10.1016/j.ebiom.2021.103488 | DOI Listing |
Medicine (Baltimore)
August 2025
Guangzhou University of Chinese Medicine, Guangzhou, China.
Rheumatoid arthritis (RA) is a prevalent autoimmune disorder that significantly reduces quality of life and imposes a substantial burden on society. This study addresses the critical gaps in current diagnostic and therapeutic modalities by aiming to identify improved biomarkers and potential therapeutic targets. Using data from 2 gene expression omnibus databases, we executed a comprehensive differential gene expression analysis integrated with Mendelian randomization.
View Article and Find Full Text PDFbioRxiv
August 2025
Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, 43210, USA.
The cytokines interleukin (IL)-22 and IL-17 are secreted by innate and adaptive immune cells to drive "type III" responses that protect against extracellular pathogens, promote mucosal barrier integrity, and foster microbiota homeostasis. However, dysregulation of IL-22 and/or IL-17 contributes to autoimmunity, chronic inflammation, and malignancy. Thus, a deeper understanding of mechanisms regulating type III cytokine production could provide new therapeutic targets for a spectrum of immune-mediated diseases.
View Article and Find Full Text PDFJ Allergy Clin Immunol
July 2025
Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland; Norwegian Centre for Molecular Biosciences and Medicine (NCMBM), University of Oslo, Oslo, Norway; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway. Electronic address: j.s.saare
Background: MAP4K1 encodes hematopoietic progenitor kinase 1 (HPK1), a serine/threonine kinase that negatively regulates T-cell receptor signaling via phosphorylation of the adaptor proteins SLP-76 (Src homology 2 domain-containing leukocyte protein of 76 kDa) and Gads. While common MAP4K1 variants have been implicated in polygenic immune-mediated diseases, the impact of rare germline variants on human immunity remains undefined.
Objective: We investigated the immunologic and functional consequences of HPK1 deficiency in individuals with suspected inborn errors of immunity.
Poult Sci
June 2025
College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, China.; Key Laboratory of Animal Production, Product Quality and Security, Jilin Agricultural University, Ministry of Education, Changchun 130118, China; Joint Laboratory of Modern Agricultural Technology Inte
Feather follicle development is essential for the phenotypic characteristics and economic value of domesticated geese. In this study, we conducted a comparative transcriptomic analysis to explore the breed-specific molecular mechanisms involved in feather follicle development in Zhedong white goose (Anser cygnoides) and Hungarian white goose (Anser anser) at five critical embryonic stages (E10, E13, E18, E23, and E28). A total of 19,622 differentially expressed genes (DEGs) were identified in geese feather follicles across the comparison groups, with significant enrichment in pathways associated with neuroactive ligand-receptor interaction, melanogenesis, tyrosine metabolism, metabolic pathways, PPAR, p53, VEGF, and Hedgehog signaling pathways.
View Article and Find Full Text PDFSci Adv
July 2025
Department of Radiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China.
Neoadjuvant therapy has been widely used in breast cancer, but treatment response varies among individuals. We conducted multiomic profiling on tumor samples from 149 Chinese patients with breast cancer across ERHER2, ERHER2, and ERHER2 subtypes, categorizing outcomes as pathologic complete response (pCR; = 81) or residual disease (RD; = 68). We identified distinct molecular features linked to pCR in each subtype: elevated cell proliferation in patients with ERHER2 pCR, higher methylation in patients with ERHER2 RD, increased methylation in patients with ERHER2 RD, and hypermethylation in patients with ERHER2 RD.
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