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http://dx.doi.org/10.1111/trf.16457 | DOI Listing |
Background: The white cell precursor (WPC) channel of the Sysmex XN-series hematology analyzer, which is designed for blast detection, showed reduced sensitivity for blast detection in leukopenic patients undergoing chemotherapy. This study aimed to evaluate the gating region for apoptotic blasts in the WPC scattergram to enhance detection sensitivity.
Methods: NOMO-1 cells, a human acute monoblastic leukemia cell line, were treated with varying concentrations of cytarabine (0, 100, 500, and 1,000 nM) for three days to induce apoptosis.
Chem Rec
September 2025
School of Physics and Mechanics, Wuhan University of Technology, Wuhan, 430070, Hubei, P. R. China.
The development of sensors for monitoring breath acetone, a key biomarker for ketosis in diabetes mellitus, represents a critical frontier in medical diagnostics, promising a painless alternative to invasive blood tests. This review provides a comprehensive and critical evaluation of the state-of-the-art in acetone gas sensing technologies, including chemiresistive, optical, electrochemical, conductometric, and microwave platforms. We focus specifically on recent breakthroughs driven by advanced materials, analyzing how novel nanostructures from two-dimensional (2D) materials such as MXenes to porous metal-organic frameworks (MOFs) are engineered to push performance to clinically relevant parts-per-billion (ppb) sensitivity.
View Article and Find Full Text PDFBiol Psychiatry
September 2025
Department of Psychiatry, University of Iowa, Iowa City, IA 52242; Iowa Neurosciences Institute, University of Iowa, Iowa City, IA 52242; Department of Obstetrics and Gynecology, University of Iowa, Iowa City, IA 52242. Electronic address:
Perinatal mood and anxiety disorders (PMADs) are a spectrum of mental health conditions that are the most common pregnancy-related complications in the United States. Despite great strides in developing appropriate pharmacological and psychological treatments, PMADs continue to lack biological measures for diagnosis and prediction. Such measures could be effectively utilized to subtype and mechanistically explore PMADs and appropriately leverage mental healthcare resources.
View Article and Find Full Text PDFAnn Plast Surg
September 2025
From the Department of Plastic Surgery, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Background: Early detection of vascular compromise is pivotal for successful microvascular flap reconstruction, as tissue necrosis can begin within 6 to 8 hours of circulatory impairment. Although conventional monitoring relies on subjective clinical assessment of color, temperature, and capillary refill-methods with inherent observer variability and diminished utility in patients with darker skin tones-emerging technologies offer potential for more objective evaluation. This study compared the efficacy of infrared thermography (IRT), a noninvasive modality that quantifies perfusion through precise temperature mapping, with traditional clinical methods for postoperative flap monitoring.
View Article and Find Full Text PDFFront Public Health
September 2025
Nursing Department, Peking University Third Hospital, Beijing, China.
Background: Metabolic dysfunction-associated fatty liver disease (MAFLD) refer to fatty liver disease related to systemic metabolic dysregulation, which is closely related to unhealthy lifestyles such as staying up late and eating irregularly. MAFLD has become most prevalent chronic liver disease and become a high incidence disease among nurses. Health and good condition of nurses are the basis to ensure the safety and quality of life of patients.
View Article and Find Full Text PDF