98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1021/acs.orglett.1c01680 | DOI Listing |
JMIR Cancer
September 2025
Cancer Patients Europe, Rue de l'Industrie 24, Brussels, 1000, Belgium.
Background: Breast cancer is the most common cancer among women and a leading cause of mortality in Europe. Early detection through screening reduces mortality, yet participation in mammography-based programs remains suboptimal due to discomfort, radiation exposure, and accessibility issues. Thermography, particularly when driven by artificial intelligence (AI), is being explored as a noninvasive, radiation-free alternative.
View Article and Find Full Text PDFPLoS One
September 2025
Animal Welfare Program, Faculty of Land and Food Systems, The University of British Columbia, Vancouver, British Columbia, Canada.
Non-replacement dairy calves (i.e., males and females not needed for milking herd replacement) can face multiple welfare challenges due to their low economic value in the dairy and beef industries.
View Article and Find Full Text PDFNaunyn Schmiedebergs Arch Pharmacol
September 2025
Dept. of Biostatistics, All India Institute of Medical Sciences, New Delhi, India.
The purpose of this study was to investigate the efficacy and safety of add-on metformin treatment in persons with active epilepsy (a-PWE). This is a single-centric, double-blind, placebo-controlled trial randomised a-PWE (1:1) to receive either metformin (extended-release 500 mg) or matching placebo for 6 months along with background antiseizure medications. Primary outcome was percentage change in seizure frequency/month, and secondary outcomes were 50% responder rate, serum mTOR expression, and serum total antioxidant capacity (TAC), body composition analysis, quality of life (QOL), and safety assessment.
View Article and Find Full Text PDFRadiat Environ Biophys
September 2025
Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan.
Sodium orthovanadate (vanadate), a potent inhibitor of p53, has been shown in earlier work to alleviate total-body irradiation (TBI)-induced hematopoietic syndrome. However, as p53 plays a crucial role in normal spermatogenesis, its suppression may raise concerns about potential adverse effects on male reproductive function. In this study, we investigated whether vanadate exacerbates impairment of male fertility when administered for hematopoietic protection under TBI conditions.
View Article and Find Full Text PDFJ Physician Assist Educ
September 2025
Andrew P. Chastain, DMS, PA-C, is an assistant professor at Butler University, Indianapolis, Indiana.
Introduction: Artificial intelligence tools show promise in supplementing traditional physician assistant education, particularly in developing clinical reasoning skills. However, limited research exists on custom Generative Pretrained Transformer (GPT) applications in physician assistant (PA) education. This study evaluated student experiences and perceptions of a custom GPT-based clinical reasoning tool.
View Article and Find Full Text PDF