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Cardio-cerebral infarction, which refers to an acute ischemic stroke (AIS) and acute myocardial infarction (AMI) that occur concurrently, is an uncommon phenomenon with a grave prognosis. Intraluminal carotid thrombus (ICT) is an infrequently encountered cause of ischemic stroke and can be associated with an underlying hypercoagulable state. One severe yet prevalent complication of infection with Coronavirus Disease 2019 (COVID-19) is thrombosis from multi-pathway inflammatory responses. Here, we present a unique case of cardio-cerebral infarction, with a free-floating intraluminal thrombus in the left internal carotid artery, in the setting of recent COVID-19 infection, and with the etiology of both events attributed to a COVID-19 hypercoagulable state. CT perfusion imaging also showed an interesting imaging finding of hyperperfusion, which is believed to be a form of dysfunctional cerebral autoregulation.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8293395 | PMC |
http://dx.doi.org/10.3390/neurolint13020027 | DOI Listing |
Phytomedicine
August 2025
Key Laboratory of Hunan Provincial for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Hunan University of Chinese Medicine, Changsha, Hunan, 410208, China. Electronic address:
Objective: Proteomics Approach to Investigate the Mechanism of Buyang Huanwu Decoction(BYHWD) in Ameliorating Cerebral Ischemia-Reperfusion Injury through Inhibition of Complement and Coagulation Cascade Activation.
Methods: A Rat Model of Qi Deficiency and Blood Stasis Induced Cerebral Ischemia-Reperfusion Injury Was Established Using Exhaustive Swimming Combined with Middle Cerebral Artery Occlusion Model(MCAO). The therapeutic effects were evaluated through neurological scoring, TTC staining, and HE staining.
J Ethnopharmacol
July 2025
The First Hospital of Hunan University of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, 410006, China. Electronic address:
Ethnopharmacological Significance: Huoxue Rongluo Formula (HXRLF) is a traditional Chinese medicine prescription widely used to treat ischemic stroke (IS), based on the classical therapeutic principles of nourishing yin and activating blood circulation. Preliminary clinical studies have demonstrated its effectiveness in improving neurological function and prognosis. However, the precise mechanisms by which HXRLF confers neuroprotection, especially its role in modulating ferroptosis after cerebral ischemia-reperfusion injury (CIRI), remain unclear.
View Article and Find Full Text PDFWorld J Clin Cases
July 2025
Department of Traditional Chinese Medicine, The General Hospital of Western Theater Command, Chengdu 610036, Sichuan Province, China.
Background: Simultaneous acute ischemic stroke (AIS) and myocardial infarction (cardiocerebral ischemic attack) have rarely been reported in the literature. Currently, no clear evidence-based guidelines or clinical trials exist to determine the optimal therapeutic strategy for these patients.
Case Summary: We present the case of a 27-year-old Chinese man who simultaneously experienced acute concomitant cerebrocardiac infarction (CCI) and painless ST-elevation myocardial infarction.
Cureus
June 2025
Department of Neurosurgery, Fuji City General Hospital, Fuji, JPN.
Brain computed tomography (CT) perfusion imaging is essential for determining patient eligibility for mechanical thrombectomy in wake-up stroke cases. CT scanning is also valuable for enabling simultaneous whole-body imaging, which supports access route evaluation and helps exclude differential diagnoses such as aortic dissection. In this report, we describe comprehensive brain perfusion CT and whole-body imaging for diagnostic evaluation in a 91-year-old female patient who presented to the emergency department with a suspected wake-up stroke.
View Article and Find Full Text PDFChin Med
July 2025
Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Hunan University of Chinese Medicine, Changsha, 410208, China.
Background: Buyang Huanwu Decoction (BYHWD), a traditional Chinese medicine formula for cerebral infarction, exerts neuroprotective effects by enhancing cerebral energy metabolism, yet its precise mechanisms remain elusive.
Objective: To explore the effects of BYHWD on improving cerebral ischemia-reperfusion injury (CIRI) with Qi deficiency and blood stasis syndrome from an energy metabolism perspective and verify it through experiments.
Methods: A rat model of CIRI with Qi deficiency and blood stasis syndrome was established and intervened with BYHWD.