Protecting the brain from stroke: Huoxue Rongluo formula (HXRLF) targets ferroptosis for neuroprotection.

Ethnopharmacological Significance: Huoxue Rongluo Formula (HXRLF) is a traditional Chinese medicine prescription widely used to treat ischemic stroke (IS), based on the classical therapeutic principles of nourishing yin and activating blood circulation. Preliminary clinical studies have demonstrated its effectiveness in improving neurological function and prognosis. However, the precise mechanisms by which HXRLF confers neuroprotection, especially its role in modulating ferroptosis after cerebral ischemia-reperfusion injury (CIRI), remain unclear.

Enhanced microalgal toxicity due to polystyrene nanoplastics and cadmium co-exposure: From the perspective of physiological and metabolomic profiles.

As important emerging contaminants, nanoplastics can act as vectors for other environmental pollutants, resulting in their migration throughout ecosystems and altering their toxicity. In this study, the fluorescent dye label aggravated the toxicity of polystyrene (PS) nanoplastics (100 nm diameter particles) to microalgae Euglena gracilis. Therefore, the toxicity of non-fluorescent labelled PS alone and in combination with divalent cadmium (Cd) on Euglena gracilis in the environmentally relevant concentrations was investigated.

Exposure of microalgae Euglena gracilis to polystyrene microbeads and cadmium: Perspective from the physiological and transcriptional responses.

Micro(nano)plastics (MPs/NPs) are already present as contaminants in the natural environment globally and have been shown to be difficult to degrade, resulting in the potential for ecological damage and public health concerns. However, the adverse effects of exposure to MPs/NPs by aquatic organisms, especially freshwater microalgae, remains unclear. In the present study, the growth, physiology and transcriptome of the freshwater microalgae Euglena gracilis were comprehensively analyzed following exposure to 1 mg/L of polystyrene (PS) microbeads (5 μm PS-MPs and 100 nm PS-NPs), 0.

Adverse physiological and molecular level effects of polystyrene microplastics on freshwater microalgae.

Microplastics have aroused widespread concern because of their adverse effects on aquatic organisms. However, the underlying toxicity mechanisms have not been examined in detail. This study investigated the interactions between polystyrene microplastics (PS-MPs) and the model freshwater microalgae Euglena gracilis.

[Effects of Microplastics on the Growth, Physiology, and Biochemical Characteristics of Wheat ()].

The toxicological effects of microplastics in the soil environment have gradually attracted widespread attention, while less is known about the influence of microplastics on plants. The growth of wheat, photosynthetic pigment content, soluble protein content, and the antioxidant enzyme activities of leaves were investigated to explore the toxic effects of microplastics on wheat (). In this study, 100 nm and 5 μm polystyrene microplastics (PS-MPs) were used for soil culture treatment combined with hydroponic growth.

Ecotoxicity and genotoxicity of polystyrene microplastics on higher plant Vicia faba.

Nano- and microplastics have been widely spread in environmental matrices, especially in marine and terrestrial systems. In this study, higher plant Vicia faba root tips were exposed to 5 μm and 100 nm with 10, 50 and 100 mg/L polystyrene fluorescent microplastics (PS-MPs) for 48 h. Root length, weight, oxidative stress and genotoxicity of V.