Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Endometrial cancer (EC) is one of the most common gynecological cancers worldwide. Sentinel lymph node (SLN) status could be a major prognostic factor in evaluation of EC, but several prospective studies need to be performed. Here we report an in-depth proteomics analysis showing significant variations in the SLN protein landscape in EC. We show that SLNs are correlated to each tumor grade, which strengthens evidence of SLN involvement in EC. A few proteins are overexpressed specifically at each EC tumor grade and in the corresponding SLN. These proteins, which are significantly variable in both locations, should be considered potential markers of overall survival. Five major proteins for EC and SLN (PRSS3, PTX3, ASS1, ALDH2, and ANXA1) were identified in large-scale proteomics and validated by immunohistochemistry. This study improves stratification and diagnosis of individuals with EC as a result of proteomics profiling of SLNs.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233695 | PMC |
| http://dx.doi.org/10.1016/j.xcrm.2021.100318 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Multicellular tumor-stromal interactions recapitulate aspects of therapeutic response and human oncogenic signaling in a 3D disease model for H3K27M-altered DIPG.
Oncogene
September 2025
Division of Neurosurgery, Children's Hospital Los Angeles, Los Angeles, CA, USA.
It has become evident from decades of clinical trials that multimodal therapeutic approaches with focus on cell intrinsic and microenvironmental cues are needed to improve understanding and treat the rare, inoperable, and ultimately fatal diffuse intrinsic pontine glioma (DIPG), now categorized as a diffuse midline glioma. In this study we report the development and characterization of an in vitro system utilizing 3D Tumor Tissue Analogs (TTA), designed to replicate the intricate DIPG microenvironment. The innate ability of fluorescently labeled human brain endothelial cells, microglia, and patient-derived DIPG cell lines to self-assemble has been exploited to generate multicellular 3D TTAs that mimic tissue-like microstructures, enabling an in- depth exploration of the spatio-temporal dynamics between neoplastic and stromal cells.
View Article and Find Full Text PDFA Distinct Immunological Signature in Late-Onset Myasthenia Gravis: Insights from an Exploratory Proteomics Study.
Ann Neurol
September 2025
Department of Neurology & Rehabilitation Medicine, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA.
Objective: Approximately 80% of patients with myasthenia gravis (MG) have autoantibodies against acetylcholine receptor, and clinical characteristics may vary between early-onset (symptom onset age <50 years) and late-onset MG (EOMG and LOMG), but the pathophysiological differences between EOMG and LOMG are not well established.
Methods: We performed an exploratory in-depth proteomics analysis examining 768 inflammatory proteins utilizing the baseline serum samples from the BeatMG study (NCT02110706). We performed pathway enrichment analysis to assess the pathways involved in LOMG.
Blood， which forms part of the systemic circulatory system， contains proteins from various tissues and organs. Hence， blood samples are ideal vehicles for studying diseases and physiological states. Plasma is an important component of blood and is essential for clinical proteomics research.
View Article and Find Full Text PDFA stepwise ionic liquid extraction method for plant leaf protein extraction.
Anal Chim Acta
October 2025
Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research of Ministry of Education, Key Laboratory of Phytochemical R&D of Hunan Province, Institute of Interdisciplinary Studies, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, 410081, China.
Background: Protein extraction from plant leaves is a key step in plant proteomics analysis. However, traditional methods often face challenges, including low efficiency, incomplete protein coverage, and environmental concerns. These limitations highlight the need for developing more efficient and environmentally friendly extraction techniques.
View Article and Find Full Text PDFProteomic insights into the multi-target mechanism and therapeutic application of citronellol-loaded carboxymethyl chitosan-based hydrogel for wound infection treatment.
Int J Biol Macromol
August 2025
State Key Laboratory of Bio-based Fiber Materials, National Engineering Lab for Textile Fiber Materials and Processing Technology, School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, PR China. Electronic address:
Methicillin-resistant Staphylococcus aureus (MRSA) continues to challenge wound care due to its strong biofilm-forming ability and resistance to conventional antibiotics. In this study, we developed a novel multifunctional hydrogel by incorporating citronellol, a bioactive monoterpenoid, into a carboxymethyl chitosan-hyaluronic acid (CMCS-HA) matrix, yielding a biocompatible platform with potent anti-MRSA activity. Unlike many previous phytocompound-based hydrogels, our work provides in-depth mechanistic insights into citronellol's antibacterial and antivirulence actions through proteomics coupled with STRING network analysis.
View Article and Find Full Text PDF