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By employing a silica-coated magnetite as a catalyst, a silica-catalyzed carboxylative cyclization of propargylic amines with carbon dioxide (CO) proceeded to afford the corresponding 2-oxazolidinones. Moreover, after the reaction, the silica-coated magnetic catalyst was readily recovered by use of an external magnet and could be reused up to six times without deactivation.
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http://dx.doi.org/10.1248/cpb.c21-00200 | DOI Listing |
Org Lett
September 2025
Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research, Ministry of Education, Key Laboratory of the Assembly and Application of Organic Functional Molecules of Hunan Province, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, China.
Cyclization of -dibromo tetrapyrrolic Ni complex with KS, NaSe, and NaTe gave Ni 5-sulfacorrole, Ni 5-selenacorrole, and Ni 5-telluracorrole, respectively, as the first example of 5-heterocorrole. The corresponding Cu 5-heterocorroles were similarly synthesized from Cu complex , while Ni 5-oxacorrole was synthesized by reaction of with Ni(cod) and 2,2'-bipyridine and subsequent oxygen-insertion reaction of molecular oxygen, and Cu 5-oxacorrole was obtained from reaction of with Cu thiophene-2-carboxylate (CuTC) and tetrabutylammonium hydroxide. Moderate aromatic characters of the Ni 5-heterocorroles are evinced by the H NMR chemical shifts, the absorption spectra, and DFT calculations.
View Article and Find Full Text PDFMolecules
August 2025
Department of Organic Chemistry, University of Chemistry and Technology, Prague, Technická 5, 166 28 Prague, Czech Republic.
The stereoselective synthesis of trisubstituted alkenes has become a key topic in modern organic chemistry. At the same time, trisubstituted alkenes also serve as valuable starting materials for a wide range of transformations. However, it remains unclear to what extent these alkenes are utilized in comparison to their mono- and disubstituted counterparts.
View Article and Find Full Text PDFOrg Biomol Chem
August 2025
Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, 31-4 Leninsky Prosp., 119071 Moscow, Russian Federation.
A new approach to synthesize peptidomimetics consisting of α-aza-amino acid and β-amino acid residues, namely β-(4-semicarbazono)- and β-(4-semicarbazido)carboxylic acids, and their esters and hydrazides has been developed. The synthesis involves the amidoalkylation of diethyl malonate with 2-unsubstituted and 2-methyl-substituted 1-arylidene-4-(tosylmethyl)semicarbazides followed by hydrolysis, decarboxylation and substitution reactions. Acid-promoted cyclization of β-(4-semicarbazido)carboxylic acid hydrazides to derivatives of 3-amino-5,6-dihydrouracils has been also investigated.
View Article and Find Full Text PDFMed Chem
August 2025
Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam, Tirupati, Andhra Pradesh, India.
Introduction: Despite significant progress in cancer treatment, the need for new anticancer agents remains critical. Current research efforts are directed toward discovering novel compounds that exhibit potent cytotoxic activity while minimizing adverse effects. Thus, tetrazole derivatives have gained attention due to their potential biological activities, including anticancer effects.
View Article and Find Full Text PDFJ Hazard Mater
August 2025
College of Chemistry and Materials Engineering, Zhejiang A&F University, Hangzhou 311300, China. Electronic address:
Imine-linked covalent organic frameworks (COFs) are considered as promising adsorbents to remove the water contaminants. However, the reversibility and hydrolyzation of imine bond may generate limited stability in long-term aqueous environment-based applications, and the improved stability of imine-linked COFs is highly desired. In this work, a carboxyl-quinoline linked COFs (CQ-COF) was synthesized by the cyclization of imine linkage via one-step modification.
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