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Spatial prioritization is a critical step in conservation planning, a process designed to ensure that limited resources are applied in ways that deliver the highest possible returns for biodiversity and human wellbeing. In practice, many spatial prioritizations fall short of their potential by focusing on places rather than actions, and by using data of snapshots of assets or threats rather than estimated impacts. We introduce spatial action mapping as an approach that overcomes these shortfalls. This approach produces a spatially explicit view of where and how much a given conservation action is likely to contribute to achieving stated conservation goals. Through seven case examples, we demonstrate simple to complex versions of how this method can be applied across local to global scales to inform decisions about a wide range of conservation actions and benefits. Spatial action mapping can support major improvements in efficient use of conservation resources and will reach its full potential as the quality of environmental, social, and economic datasets converge and conservation impact evaluations improve.
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http://dx.doi.org/10.1111/nyas.14651 | DOI Listing |
NPJ Precis Oncol
September 2025
Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Breast cancer is a highly heterogeneous disease with diverse outcomes, and intra-tumoral heterogeneity plays a significant role in both diagnosis and treatment. Despite its importance, the spatial distribution of intra-tumoral heterogeneity is not fully elucidated. Spatial transcriptomics has emerged as a promising tool to study the molecular mechanisms behind many diseases.
View Article and Find Full Text PDFMar Pollut Bull
September 2025
CSIR-National Institute of Oceanography, Dona Paula, Goa, 403004, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
The Indian Sundarban Delta (ISD), located at the confluence of the Ganga-Brahmaputra-Meghna river system along India's eastern coast, is among the world's most geomorphologically dynamic and environmentally vulnerable deltaic systems. Over the past five decades, the region has undergone substantial morphodynamic changes driven by natural forces such as relative sea-level rise, wave action, and sediment flux, as well as anthropogenic factors like upstream water regulation via dams and barrages. This study examines the long-term evolution of shoreline and island morphology across the ISD from 1972 to 2025 using multi-temporal Landsat datasets under consistent tidal conditions.
View Article and Find Full Text PDFPLoS One
September 2025
Maine Department of Inland Fisheries and Wildlife, Bangor, Maine, United States of America.
Freshwater mussels are critical to the health of freshwater systems, but their populations are declining dramatically throughout the world. The limited resources available for freshwater mussel conservation necessitates the geographic prioritization of conservation-related actions. However, lack of knowledge about freshwater mussel spatial distributions hinders decision making in this context.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2025
Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37240.
Major depressive disorder affects millions worldwide, yet current treatments require prolonged administration. In contrast, ketamine produces rapid antidepressant effects by blocking spontaneous N-Methyl-D-Aspartate (NMDA) receptor signaling, which lifts the suppression of protein synthesis and triggers homeostatic synaptic plasticity. Here, we identify a parallel signaling pathway involving metabotropic glutamate receptor 5 (mGluR5) that promotes rapid antidepressant-like effects.
View Article and Find Full Text PDFElife
September 2025
Department of General Psychology, University of Padua, Padova, Italy.
Humans order numerosity along a left-to-right mental number line (MNL), traditionally considered culturally rooted. Yet, some species at birth show spatial-numerical associations (SNA), suggesting neural origins. Various accounts link SNA to brain lateralization but lack evidence.
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