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Aim: The objective of this study was to verify the reliability and validity of the Dementia Assessment Sheet for Community-based Integrated Care System 21 items (DASC-21) among Chinese community-dwelling older adults, and to explore the related factors for dementia screening.
Methods: The study adopted a cross-sectional design, and a total of 1152 participants aged ≥60 years were recruited from 26 locations in China. All data were collected using questionnaires through face-to-face interviews. The logistic regression model was used to evaluate the effect factors of DASC-21 for dementia screening. The receiver operating characteristic curves were used to determine the optimal cut-off points and the accuracy of the DASC-21 for dementia and mild cognitive impairment screening.
Results: For test-retest reliability, the Pearson correlation coefficient was 0.873 (P < 0.001). In the criterion-related validity, the DASC-21 scores were significantly and negatively correlated with the Mini-Mental State Examination (r = -0.663, P < 0.001) and the Montreal Cognitive Assessment (r = -0.565, P < 0.001) scores. The results of the receiver operating characteristic analysis showed that there were different optimal cut-off values for different age groups. The areas under the receiver operating characteristic curves were 95.6% and 90.3% for dementia and mild cognitive impairment screening using DASC-21 after considering related effect factors.
Conclusions: The DASC-21 was confirmed to be a valid and reliable instrument for dementia screening among Chinese community-dwelling older adults. Our results suggested that the age, education level and 2-week prevalence were important effect factors for dementia screening using the DASC-21. Geriatr Gerontol Int 2021; 21: 705-711.
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http://dx.doi.org/10.1111/ggi.14215 | DOI Listing |
J Gerontol A Biol Sci Med Sci
September 2025
Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing, MI.
Background: Poor olfaction may be associated with incident heart failure (HF) in older adults, but empirical evidence is scant.
Methods: We included 5,217 participants free of clinical HF and with a smell assessment in 2011-2013 from the Atherosclerosis Risk in Communities Study. Olfaction was measured by the 12-item Sniffin' Sticks odor identification test and defined as good (score 11-12), moderate (9-10), or poor (≤8).
Ann Acad Med Singap
August 2025
Dementia Research Centre (Singapore), Lee Kong Chian School of Medicine, Nanyang Technology University, Singapore.
Introduction: Interpretation and analysis of magnetic resonance imaging (MRI) scans in clinical settings comprise time-consuming visual ratings and complex neuroimage processing that require trained professionals. To combat these challenges, artificial intelligence (AI) techniques can aid clinicians in interpreting brain MRI for accurate diagnosis of neurodegenerative diseases but they require extensive validation. Thus, the aim of this study was to validate the use of AI-based AQUA (Neurophet Inc.
View Article and Find Full Text PDFJ Alzheimers Dis
September 2025
Paula Costa-Urrutia Medical Affairs, Terumo BCT, Edificio Think MVD, Montevideo, Uruguay.
BackgroundTherapeutic plasma exchange (TPE) with albumin replacement has emerged as a potential treatment for Alzheimer's disease (AD). The AMBAR trial showed that TPE could slow cognitive and functional decline, along with changes in core and inflammatory biomarkers in cerebrospinal fluid.ObjectiveTo evaluate the safety and effectiveness of TPE in a real-world setting in Argentina.
View Article and Find Full Text PDFJAMA Psychiatry
September 2025
Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville.
Importance: Behavioral variant frontotemporal dementia (bvFTD), the most common subtype of FTD, is a leading form of early-onset dementia worldwide. Accurate and timely diagnosis of bvFTD is frequently delayed due to symptoms overlapping with common psychiatric disorders, and interest has increased in identifying biomarkers that may aid in differentiating bvFTD from psychiatric disorders.
Objective: To summarize and critically review studies examining whether neurofilament light chain (NfL) in cerebrospinal fluid (CSF) or blood is a viable aid in the differential diagnosis of bvFTD vs psychiatric disorders.
J Alzheimers Dis
September 2025
Department of Community Health and Health Behavior, University at Buffalo, Buffalo, NY, USA.
BackgroundFear of developing Alzheimer's disease and other dementias could motivate defensive responses to dementia information, including public health messaging, and reduce willingness to undergo screening or diagnostic testing for the disease.ObjectiveWe sought to assess the pervasiveness of dementia information avoidance and test whether it is associated with lower willingness to be screened for dementia. We also tested whether lower generalized self-efficacy is associated with higher dementia information avoidance, as the former might be a point of intervention for decreasing defensive information avoidance.
View Article and Find Full Text PDF