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Optical coherence tomography (OCT) was used for imaging three-dimensional fingerprint to overcome the effects of different skin states and fake fingerprint. However, the OCT-based fingerprint features depend on the depth of fingertip skin which is still challenging for biometric recognition and encryption. In this work, we presented a new approach of maximum intensity projection (MIP) image of the epidermal-dermal junction (DEJ) to extract the internal fingerprint that is independent of the depth of fingertip skin. To begin with, the surface and DEJ were segmented based on the deep learning algorithm. Then the internal fingerprint was extracted by the MIP image of DEJ which has a more accurate structural similarity by quantitative analysis. The experimental results showed that internal fingerprint acquired by MIP of DEJ can be applied for scar-simulation fingertip and encryption since it is not sensitive to the states of surface skin and independent of the depth.
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http://dx.doi.org/10.1364/OE.421312 | DOI Listing |
Protein Sci
September 2025
Institute for Personalized Medicine, Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
The identification of succinct, universal fingerprints that enable the characterization of individual taxonomies can reveal insights into trait development. Here, we introduce taxonomic quasi-primes, peptide k-mer sequences that are exclusively present in a specific taxonomy and absent from all others. By analyzing 24,073 reference proteomes, we identified these unique peptides at the superkingdom, kingdom, and phylum ranks.
View Article and Find Full Text PDFAnalyst
August 2025
Department of Thoracic Surgical Oncology, Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Exosomes are critical biomarkers for early cancer diagnosis and prognosis due to their rich biological information. Nevertheless, analyzing exosomal biomarkers comprehensively remains challenging. Surface-enhanced Raman scattering (SERS) has been employed to detect exosomes due to its high sensitivity and reliable fingerprint.
View Article and Find Full Text PDFTalanta
August 2025
School of Science, Xihua University, Chengdu, 610039, PR China. Electronic address:
Surface-enhanced Raman spectroscopy (SERS), an ultrasensitive molecular fingerprinting technique, requires substrates that synergistically integrate electromagnetic field amplification (via plasmonic hotspots) and analyte enrichment (through nanoscale molecular confinement). Although metal nanoparticles (NPs) generate hotspots, their practical utility is hindered by chemical instability, poor reproducibility, and weak analyte affinity. Covalent organic frameworks (COFs), with designable porosity, ultrahigh surface areas, and stability, offer a promising platform to address these limitations.
View Article and Find Full Text PDFJ Ethnopharmacol
August 2025
The School of Computer Science Guangdong University of Education Guangzhou, China. Electronic address:
Research Purpose: This study proposes MMFi-DPBML, a deep learning framework that in-tegrates multi-molecular fingerprint features for predicting ingredient-target interactions (ITIs) in traditional Chinese medicine (TCM). By capturing di-verse structural and physicochemical features, the model aims to enhance prediction accuracy and support TCM modernization through data-driven approaches.
Method: MMFi-DPBML fuses four types of molecular fingerprints-MACCS, ECFP4, Torsion, and 2D Pharmacophore-alongside 20 molecular descrip-tors, processed through a Deep Pyramid Convolutional Neural Network (DPCNN).
Anal Chim Acta
October 2025
College of Chemistry and Materials Engineering, Anhui Science and Technology University, Bengbu, 233030, PR China; Anhui Province Quartz Sand Purification and Photovoltaic Glass Engineering Research Center, Chuzhou, 233100, PR China. Electronic address:
Exploring the internal relationship between the structure and properties of AIE-active iridium complexes and their applications have been great significance. It is imperative to acknowledge that the precise control of nanoparticle morphology and particle size of organic molecules in solutions remains elusive, while comprehending the luminescent mechanisms of self-assembled aggregates continues to present a challenge. The previously work proposed that solvent-induced amphiphilic molecules could enhance the self-assembly properties of iridium complexes, but the influence of ligands' hydrophilic-lipophilic interactions on the AIE characteristics of iridium complexes remained unclear.
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