Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Aim: To investigate relationship between refractive errors and eleven single nucleotide polymorphisms (SNPs) in , and genes in Turkish population.
Methods: A group of 212 participants with myopia (=91), hyperopia (=45), and emmetropia (=76) were investigated in this study. SNPs in and genes were studied by SnapShot technique.
Results: The patients in this study consists of 47 female/44 male (age: 23.47±4.30) patients with myopia, 20 female/25 male (age: 31.20±8.02) with hyperopia and 33 female/43 male (age: 25.22±6.60) with emmetropia. The genotype distribution of the rs7618348 polymorphism, which was the only statistically significant one between myopia and emmetropia group. The genotype distribution of the rs3819545, rs3735520, rs7041, and rs2239182 polymorphisms, which were statistically significant between hyperopia and emmetropia groups.
Conclusion: The importance of genetic predisposition to refractive errors with respect to etiology of the disease is revealed. It is known that polymorphism studies may differ because of genetic diversity among populations so larger cohort studies are required in different populations to enlighten the etiology of the refractive errors.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8165615 | PMC |
| http://dx.doi.org/10.18240/ijo.2021.06.05 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Novel Grm6 Variant in a no b-wave (nob) Mouse Model: Phenotype Characterization and Gene Therapy.
Invest Ophthalmol Vis Sci
September 2025
Department of Ophthalmology, Edward S. Harkness Eye Institute, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, Columbia University, New York, New York, United States.
Purpose: To characterize a no b-wave (nob) mouse model of congenital stationary night blindness (CSNB) caused by a Grm6 variant that disrupts photoreceptor-to-bipolar cell signaling. Additionally, we aim to evaluate the efficacy of gene therapy in restoring visual function.
Methods: The nob mouse was generated through selective breeding to regenerate the nob phenotype.
Structure-Function Associations of Choroidal Thickness With Retinal Sensitivity in Myopia.
Invest Ophthalmol Vis Sci
September 2025
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Purpose: The purpose of this study was to investigate the focal relationship between choroidal thickness and retinal sensitivity in myopic eyes.
Methods: Participants underwent swept-source optical coherence tomography (SS-OCT) imaging and microperimetry testing. Choroidal thicknesses were obtained by segmenting the SS-OCT scans using a deep-learning approach.
Acute Accommodative Insufficiency After LASIK Due to COVID-19 Infection.
J Refract Surg
September 2025
Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio.
Purpose: To report a case of acute and transient accommodative insufficiency after laser in situ keratomileusis (LASIK) due to coronavirus disease 2019 (COVID-19).
Methods: Case report and literature review.
Results: A 36-year-old man complained of acute blurred near vision 7 days after uneventful bilateral hyperopic LASIK, concurrent with the onset of COVID-19 infection.
The Effects of Ambient Temperature and Ablation Interruption on Thermal Load During Excimer Laser Ablation.
J Refract Surg
September 2025
Department of Refractive Surgery, Shanghai Aier Eye Hospital, Shanghai.
Purpose: To analyze the effects of ablation interruption on ablation depths and clinical refractive outcomes to characterize the impact of ambient temperature changes and ablation interruption on ocular surface temperature (OST) during excimer laser ablation.
Methods: This prospective study was conducted on laser ablations in polymethylmethacrylate (PMMA) plates and porcine corneas to simulate laser in situ keratomileusis (LASIK) treatments using the EX500 laser (Alcon Laboratories, Inc) at ambient temperatures of 18, 20, and 22 °C. Ablation interruption was performed for 1, 2, 3, 4, and 5 seconds at the 10th second of the treatment of -9.
Efficacy of Correcting Different Types of Astigmatism With Small Incision Lenticule Extraction: A Prospective Contralateral Eye Study.
J Refract Surg
September 2025
Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Purpose: To evaluate axis-dependent visual and refractive outcomes of small incision lenticule extraction (SMILE) in patients with interocular astigmatic axis discordance.
Methods: Seventy-five patients (150 eyes) with interocular astigmatic axis discordance were included in the study. Based on interocular axis combinations, patients were stratified into three cohorts: with-the-rule (WTR)/against-the-rule (ATR) (n = 19), WTR/oblique astigmatism (OA) (n = 39), and ATR/OA (n = 17).