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Objective: Affect regulation models of drinking state that affect motivates and reinforces drinking. Few studies have been able to elucidate the timing of these associations in natural settings. We tested positive affect (PA) and negative affect (NA) as predictors of drinking behavior, both prior to and during drinking episodes, and whether drinking predicted changes in affect during episodes.
Method: Two hundred twenty-two regularly drinking young adults (21-29 years, 84% undergraduates), completed an ecological momentary assessment (EMA) protocol for five consecutive 24-hr periods stretching across 6 days (Wednesday-Monday). Participants provided PA and NA reports three times daily and every half hour during drinking episodes. Alcohol consumption reports were provided each morning and every half hour during drinking episodes.
Results: Multi-level models showed that greater pre-drinking PA predicted higher odds of drinking, but not number of drinks consumed. Pre-drinking NA did not predict same day odds of drinking or drinks consumed. Episode-level results revealed different associations for PA and NA with drinking. Current PA did not predict drinks consumed over the next half hour; however, increased drinking was associated with greater increases in PA over the next half hour. Higher NA predicted fewer drinks consumed in the next half hour and higher odds of the end of a drinking episode; however, increased drinking was not associated with changes in NA.
Conclusions: PA increased following drinking during episodes. Our results suggest that a focus on PA prior to episodes and a focus on NA during episodes may interrupt processes leading to heavy drinking, and may therefore aid prevention efforts. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
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http://dx.doi.org/10.1037/adb0000763 | DOI Listing |
Int J Pharm
September 2025
Department of Pharmaceutics, VCU School of Pharmacy, Richmond, VA 23298, USA. Electronic address:
Multiple exogenous supplements to achieve ketosis using the oral route have been developed to elevate blood BHB levels on demand and in a controllable fashion. The focus is now shifting to evaluating these supplements as potential therapeutic agents and developing strategies to not only achieve ketosis but also maintain it. One such strategy is to administer these as a continuous IV infusion.
View Article and Find Full Text PDFIndian Pediatr
September 2025
Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Objective: To determine the cyclosporine trough (C) and two-hour post-dose concentrations (C) in children with nephrotic syndrome (NS) and study the factors influencing them.
Methods: In this ambispective cohort study, children with NS (including frequently relapsing, steroid-dependent and steroid-resistant nephrotic syndrome) on cyclosporine therapy were enrolled. Clinical and laboratory data were recorded.
J Am Heart Assoc
September 2025
Division of Experimental Cardiology, Department of Cardiology Erasmus MC University Medical Center Rotterdam The Netherlands.
Background: Despite successful recanalization after endovascular thrombectomy, more than half of patients with acute ischemic stroke with large-vessel occlusions experience an unsatisfactory outcome. Incomplete microvascular reperfusion may contribute to it, but its occurrence remains debated, partly due to clinical observations of hyperperfusion after recanalization. This study investigates the relationship between ischemia duration, infarct development, microclot presence, and cerebral perfusion in a swine model of focal cerebral ischemia and reperfusion.
View Article and Find Full Text PDFAm J Vet Res
September 2025
Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, Davis, CA.
Objective: Determine the pharmacokinetic parameters of a single dose of gabapentin administered orally in healthy weaned Pacific harbor seal (HS) pups (Phoca vitulina richardii).
Methods: In the spring of 2023, rehabilitated HS pups were enrolled in this pharmacokinetic study. Seals were administered 10 mg/kg of gabapentin orally in a fish.
Front Neural Circuits
September 2025
Laboratory of Brain Development and Regeneration, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.
The coordination of various brain regions achieves both volitional and forced motor control, but the role of the primary motor cortex in proficient running motor control remains unclear. This study trained mice to run at high performance (>10,000 rotations per day or >2,700 rotations per hour) using a running wheel, and then assessed the effects of the removal of bilateral cortical areas including the primary motor cortex on volitional (self-initiated) and forced (externally driven) running locomotion. The control sham-operated group revealed a quick recovery of volitional running, reaching half of the maximum daily rotation in 3.
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