Population pharmacokinetics of a single oral dose of gabapentin identifies rapid plasma clearance in rehabilitated Pacific harbor seal pups (Phoca vitulina richardii).

Objective: Determine the pharmacokinetic parameters of a single dose of gabapentin administered orally in healthy weaned Pacific harbor seal (HS) pups (Phoca vitulina richardii).

Methods: In the spring of 2023, rehabilitated HS pups were enrolled in this pharmacokinetic study. Seals were administered 10 mg/kg of gabapentin orally in a fish.

Evaluation of Two Serologic Tests for Rapid Detection of Anti-Leptospira Antibodies in California Sea Lions (Zalophus californianus).

Leptospirosis is a bacterial zoonosis impacting wild and domestic animals globally. Leptospira interrogans serovar Pomona is endemic in free-ranging California sea lions (CSLs; Zalophus californianus), and leptospirosis is frequently diagnosed in stranded CSLs. Serum microscopic agglutination test (MAT) is a commonly performed diagnostic assay, and CSLs with clinical disease have reliably elevated MAT titers.

Comparative pharmacokinetics of a single oral dose of meloxicam in the California sea lion (Zalophus californianus) and Pacific harbor seal (Phoca vitulina richardii).

Pharmacokinetics studies have investigated meloxicam, a non-steroidal anti-inflammatory drug, dosing strategies in a wide variety of non-domestic animals; however, there is no prior study examining well-founded dosing for pinnipeds. To develop dosing protocols, pharmacokinetic information is needed, with an examination of differences between pinniped species. Apparently, healthy California sea lions (Zalophus californianus: CSL; n = 13) and Pacific harbor seals (Phoca vitulina richardii: PHS; n = 17) that had completed rehabilitation were enrolled into a population-based pharmacokinetic study.