The Preliminary Study for Postoperative Radiotherapy Survival Associated with and Expression in Lung Cancer.

Background: Many studies have reported that the inflammatory immune response related to signaling activation participates in tumor development and affects the treatment outcome. functions as a tumor suppressor by regulating DNA methylation. protein plays an important role in TGF-β signaling pathway that is involved in tumor growth inhibition and apoptosis. At present, radiotherapy is still an important treatment in lung cancer, which induces immune response and affects the therapeutic outcome. The role of signaling activation and in this process is not clear.

Methods: In this study, we investigated the expression of in tumor and in surrounding tissues by immunohistochemical methods and analyzed the relationship on postoperative survival in lung cancer.

Results: We found that the high expression of was the risk factor in postoperative survival of lung cancer with no difference in lifetime. The high expression of in lung cancer with signaling activation was in favor of progression-free survival and overall survival in postoperative radiotherapy. It suggested that played an important role in lung cancer radiotherapy. In order to determine the effect of in lung cancer radiation with signaling activation, we introduced 5-Aza-2'-deoxycytidine (5-Aza-CdR) and exposed lung cancer A459 cells repeatedly. The high expression of especially -B in cells treated with 5-Aza-CdR was observed. We examined that 5-Aza-CdR induced more cell blocking in G2/M phase in combining irradiation.

Conclusion: The result implied that it was feasible to improve radiosensitivity of lung cancer with signaling activation by increasing expression, and 5-Aza-CdR was an option in this process.