Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Purpose: Serotonin (5-HT) is highly associated with pain modulation. The human 5-HT transporter (5-HTT) gene (SLC6A4) features several polymorphisms in its promoter region (5-HTTLPR) that affect the 5-HTT expression. The S allele of 5-HTTLPR induces low 5-HT tone, and it may influence the modulation of chronic pain. Meanwhile, pain occurs in 40-50% of patients after thoracic surgery, and its mechanism remains under investigation. This study assessed the role of 5-HTTLPR polymorphisms in postthoracotomy pain severity.
Patients And Methods: A total of 178 patients undergoing pneumonectomy were enrolled. The genotypes of 5-HTTLPR were divided into two groups: S/S group and S/L or L/L group. Linear mixed-effects models were used to assess the association between 5-HTTLPR genotypes and the numerical rating scale (NRS) score change over time.
Results: Among the participants, data were obtained for 162 patients. The genotype distribution was as follows: S/S, 67.3%; S/L or L/L, 32.7%. No significant difference in patient characteristics was found between the genotype groups. There was no significant interaction between the 5-HTTLPR genotypes and the NRS score change over time (p = 0.842).
Conclusion: Polymorphisms in 5-HTTLPR were not associated with postthoracotomy pain severity.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164694 | PMC |
| http://dx.doi.org/10.2147/JPR.S298685 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Analgesic efficacy of continuous ultrasound-guided unilateral erector spinae block and thoracic epidural analgesia in patients undergoing antero-lateral thoracotomy.
World J Methodol
December 2025
Department of Trauma and Emergency Medicine, All India Institute of Medical Sciences, Bhopal 462024, Madhya Pradesh, India.
Background: Chest physiotherapy and incentive spirometry, essential for pulmonary care, can exacerbate acute post-thoracotomy pain. Pain relief is, therefore, essential to facilitate early mobilization. This study evaluated the analgesic efficacy of unilateral continuous erector spinae block (ESB) compared to thoracic epidural analgesia (TEA) in terms of quality of pain relief and perioperative hemodynamic changes.
View Article and Find Full Text PDFIpsilateral High Thoracic Ultrasound-Guided Erector Spinae Plane Block for Post-Thoracotomy Shoulder Pain in Thoracic Cancer Surgeries: A Randomized Controlled Clinical Trial.
J Cardiothorac Vasc Anesth
July 2025
Anesthesia, Surgical Intensive Care, and Pain Relief Department, National Cancer Institute, Cairo University, Cairo, Egypt.
Objectives: To assess the safety and efficacy of ultrasound-guided high thoracic erector spinae plane block (HT-ESPB) in the management of post-thoracotomy ipsilateral shoulder pain (PTISP).
Design: Randomized, double-blind, parallel-group, controlled, clinical trial.
Setting: The National Cancer Institute.
Ultrasound-guided external oblique intercostal plane block versus thoracic erector spinae block for post-thoracotomy pain: A randomised double-blinded non-inferior clinical study.
Indian J Anaesth
August 2025
Anesthesiology, Surgical Intensive Care and Pain Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt.
Background And Aims: Regional techniques are preferred for controlling post-thoracotomy pain due to lower complication rates. This study aimed to compare the analgesic efficacy and safety of ultrasound-guided external oblique intercostal block (EOIB) with thoracic erector spinae plane block (ESPB) for post-thoracotomy pain.
Methods: This randomised, double-blind, non-inferior clinical study involved 60 cases scheduled for thoracic surgery.
Analgesic efficacy of ultrasound guided erector spinae plane block versus serratus anterior plane block in pediatric patients undergoing aortic coarctectomy; a randomized controlled study.
BMC Anesthesiol
July 2025
Anesthesiology, Surgical Intensive Care and Pain Management Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Background: Aortic coarctectomy (AC) is associated with marked intraoperative hemodynamic alterations and significant post-thoracotomy pain. In this study, the analgesic effects of erector spinae plane block (ESPB) and serratus anterior plane block (SAPB) were compared.
Methods: 28 pediatric patients were randomized into the ESPB group (received unilateral ESPB using a volume of 0.
Optimizing post-thoracotomy pain management: comparing erector spinae vs. paravertebral block in thoracotomy patients: a prospective randomized study.
BMC Anesthesiol
July 2025
Department Of Anesthesiology And Reanimation Clinic, Health Ministery Basaksehir Cam And Sakura City Hospital, Basaksehir, Istanbul, Turkey.
Background: Postoperative pain can lead to serious complications in the short and medium term. It may also increase the risk of converting acute pain into chronic pain, leading to the development of postthoracotomy pain syndrome (PTPS). The aim of this study was to demonstrate the effectiveness of erector spinae plane block (ESPB) and paravertebral block (PVB) in managing acute postoperative pain and preventing the development of PTPS in patients undergoing thoracotomy and lobectomy.
View Article and Find Full Text PDF